Digestive Diseases and Sciences

, Volume 40, Issue 7, pp 1538–1541 | Cite as

Natural killer cell activity in patients with pernicious anemia

  • J. A. Vargas
  • M. Alvarez-Mon
  • L. Manzano
  • A. Albillos
  • A. Fernández-Corugedo
  • J. C. Gea-Banacloche
  • F. M. Gonzalez
  • A. Durántez
Gastrointestinal Oncology
  • 18 Downloads

Abstract

Patients with pernicious anemia have an estimated risk of gastric adenocarcinoma that ranges from three- to fivefold greater than that of the general population. It has been reported that NK cells may be involved in immunosurveillance against tumor spread. The natural killer cell activity of peripheral blood mononuclear cells was analyzed in 22 patients with pernicious anemia and in 19 healthy controls. Levels of natural killer cell activity against K-562 target cells were similar in control subjects and patients, regardless of gastrin levels and time elapsed since diagnosis. According to quantitative flow cytometry analysis, similar percentages of phenotypically defined NK cells (CD16+) were found in peripheral blood mononuclear cells from patients and healthy controls. Our results show that in pernicious anemia patients, the percentage of NK cells present in peripheral blood mononuclear cells and their lytic activity are normal.

Key Words

NK cell pernicious anemia immunology gastric adenocarcinoma 

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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • J. A. Vargas
    • 1
    • 2
  • M. Alvarez-Mon
    • 1
    • 2
  • L. Manzano
    • 1
    • 2
  • A. Albillos
    • 1
    • 2
  • A. Fernández-Corugedo
    • 1
    • 2
  • J. C. Gea-Banacloche
    • 1
    • 2
  • F. M. Gonzalez
    • 1
    • 2
  • A. Durántez
    • 1
    • 2
  1. 1.Services of Internal Medicine I and Gastroenterology, Department of Medicine, Clínica Puerta de HierroUniversidad AutónomaMadridSpain
  2. 2.Service of Internal Medicine, Department of Medicine, Hospital Universitario Príncipe de Asturias, Clínica Puerta de HierroUniversidad de Alcalá de HenaresMadridSpain

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