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Omeprazole inhibits growth of cancer cell line of colonic origin

  • Gastrointestinal Oncology
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Abstract

The direct effects of omeprazole on colonic cells has not been evaluated. Controversy exists regarding the potential adverse effects of omeprazole on cell proliferation. In order to mimic thein vivo situation in the patient treated with omeprazole, proliferation cell culture experiments were performed, monitoring directly the effects of gastrin and omeprazole both alone and in combination. Three colonic cancer cell lines were used, two with neuroendocrine features (NCI-H716, LCC-18) and one (DLD-1) not known to have these features. In thesein vitro proliferation experiments, only the NCI-H716 colorectal cancer cell line responded to omeprazole by decreased proliferation (P<0.05). The effect was concentration dependent shown for all doses of omeprazole used. Gastrin had a statistically significant effect on increasing proliferation in the NCI-H716 cell line alone but only at the highest concentration (10−6M). Omeprazole has a cytostatic effect on one of three colorectal cancer cell lines but the mechanism for this effect of omeprazole and its potential role in treatment awaits elucidation.

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Authors and Affiliations

  1. Division of Gastroenterology, Department of Medicine, Harper Hospital, Wayne State University School of Medicine, 2WS 3990 John R, 48201, Detroit, Michigan

    Martin Tobi MBChB, Sreenivas Chintalapani MD, Robert Goo MD, Benedict Maliakkal MD, Jyothi Reddy MD, Monalill Lundqvist PhD, Kjell Öberg MD & Gordon Luk MD, PhD

  2. University of Uppsala, Uppsala, Sweden

    Martin Tobi MBChB, Sreenivas Chintalapani MD, Robert Goo MD, Benedict Maliakkal MD, Jyothi Reddy MD, Monalill Lundqvist PhD, Kjell Öberg MD & Gordon Luk MD, PhD

  3. Department of Medicine, Southwestern University, Dallas, Texas

    Martin Tobi MBChB, Sreenivas Chintalapani MD, Robert Goo MD, Benedict Maliakkal MD, Jyothi Reddy MD, Monalill Lundqvist PhD, Kjell Öberg MD & Gordon Luk MD, PhD

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  1. Martin Tobi MBChB
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  2. Sreenivas Chintalapani MD
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  3. Robert Goo MD
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  7. Kjell Öberg MD
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  8. Gordon Luk MD, PhD
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Tobi, M., Chintalapani, S., Goo, R. et al. Omeprazole inhibits growth of cancer cell line of colonic origin. Digest Dis Sci 40, 1526–1530 (1995). https://doi.org/10.1007/BF02285203

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  • DOI: https://doi.org/10.1007/BF02285203

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