Skip to main content

Flow resistance and its components in hypertensive men treated with the calcium antagonist isradipine

European Journal of Clinical Pharmacology volume 43, pages 463–468 (1992)Cite this article

Summary

The components of blood flow resistance were investigated in 14 men with essential hypertension (diastolic blood pressure higher or equal to 100 mmHg) before and after treatment with the dihydropyridine calcium antagonist-isradipine.

Isradipine reduced intraarterial blood pressure by decreasing the total (placebo 5.1 U · mPa−1·s−1; isradipine 3.9 U·mPa−1·s−1), and renal (placebo 48.9 U·mPa−1· s−1, isradipine 35.4 U·mPa−1·s−1) vascular hindrance, the blood viscosity being unchanged. Arterial compliance was increased by isradipine (placebo 1.03 ml·mm Hg−1; isradipine 1,25 ml·mm Hg−1). The pressor response to adrenergic alpha stimulation with phenylephrine was decreased during treatment with the calcium antagonist. The compliance of the venous system was not changed by the treatment with isradipine. Haemorheological parameters were stable throughout the study but some changes in the correlations between the different rheological parameters were observed.

The present study indicates that the antihypertensive effect of the dihydropyridine calcium antagonist isradipine was the result of functional modulation of the small and large arteries, the venous system and the flow properties of blood being unaffected.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

References

  1. Lund-Johansen P (1980) Hemodynamics in essential hypertension. Clin Sci 59 [Suppl]: 343s-354s

    Google Scholar 

  2. Scholz PM, Karis JH, Gump FE, Kinney JM, Chien S (1975) Correlation of blood rheology with vascular resistance in critically ill patients. J Appl Physiol 39:1008–1011

    Google Scholar 

  3. O'Rourke MF (1985) Basic concepts for understanding of large arteries in hypertension. J Cardiovasc Pharmacol 7 [Suppl]: 14–21

    Google Scholar 

  4. Zweifach BW (1983) The microcirculation in experimental hypertension. State-of-the-art review. Hypertension 5 [Suppl]: I10–I16

    Google Scholar 

  5. Schalekamp MADH, Man in't Veld AJ, Wenting GJ (1985) What regulates whole body autoregulation? Clinical observations. J Hypertens 3: 97–107

    Google Scholar 

  6. Dintenfass L (1981) Hyperviscosity in hypertension. Pergamon Press, Sydney

    Google Scholar 

  7. Letcher RL, Chien S, Laragh JH (1979) Changes in blood viscosity accompanying the response to prazosin in patients with essential hypertension. J Cardiovasc Pharmacol 1 [Suppl 1]: 8–20

    Google Scholar 

  8. Hopkins RJ, Hill TWK (1985) Effects of felodipine on red blood cell deformability. Drugs 29 [Suppl 2]:42–44

    Google Scholar 

  9. Stone PH, Amman EM, Muller JE, Braunwald E (1980) Calcium channel blocking agents in the treatment of cardiovascular disorders. Part 11: Hemodynamic effects and clinical applications. Ann Intern Med 93: 886–904

    Google Scholar 

  10. Safar ME, Pannier B, Laurent S, London GM (1989) Calcium entry blockers and arterial compliance in hypertension. J Cardiovase Pharmacol 14 [Suppl 10]: s1-s6

    Google Scholar 

  11. Wellens D, Goossens T, Reytjens A (1980) Posistiv hemokinetic effects after selective calcium antagonism. Angiology 31: 821–827

    Google Scholar 

  12. Waller DG, Roath OS (1986) Nifedipine and red cell deformability in angina. Clin Hemorheol 6:275–277

    Google Scholar 

  13. Waller DG, Nicholson HP, Roath OS (1984) The acut effects of nifedipine on red cell deformability in angina pectoris. Br J Clin Pharmacol 17:133–138

    Google Scholar 

  14. Perret G, Garnier M, Modigliani E, Hanss M (1984) Lack of effect of nifedipine on erythrocyte filterability and on erythrocyte membrane lipids in healthy volunteers: a double blind cross-over study. Clin Hemorheol 4:401–408

    Google Scholar 

  15. Yoneda S, Kako T, Kohketsu M, Fujinami T (1989) Changes in blood viscosity following nifedipine administration and its relation to the contents of adenosine triphosphate and 2,3-diphosphoglyceric acid in red blood cells in patients with angina pectoris. Arzneim Forsch / Drug Res 39:504–506

    Google Scholar 

  16. Koenig W, Ernst E (1990) The effects of calcium channel blockers on blood fluidity. J Cardiovasc Pharmacol 16 [Suppl 6]: S40-S44

    Google Scholar 

  17. Hof RP, Hof A, Scholtysik G, Menninger K (1984) Effects of new calcium antagonist PN-200-110 on the myocardium and regional peripheral circulation in anesthetized cats and dogs. J Cardiovasc Pharmacol 6:407–416

    Google Scholar 

  18. Andersson OK, Persson B, Hedner T, Aurell M, Wysocki M (1989) Blood pressure control and hemodynamic adaptation with the dihydropyridine calcium antagonist isradïpine: a controlled study in middle-aged hypertensive men. J Hypertens 7: 465–469

    Google Scholar 

  19. Nilsson NJ (1963) A linearly responding dichromatic cuvette densitometer for dye-dilution curves. Scand J Lab Invest 69 [Suppl]:181–193

    Google Scholar 

  20. Persson B, Wysocki M, Andersson OK (1989) Long-term renal effects of isradipine, a calcium entry blocker, in essential hypertension. J Cardiovasc Pharmacol 14: 22–24

    Google Scholar 

  21. Romer Krusell L, Tang Jespersen L, Schmitz A, Thomsen K, Lederballe Pedersen O (1987) Repetitive natriuresis and blood pressure. Long-term calcium entry blockade with isradipine. Hypertension 10: 577–581

    Google Scholar 

  22. Ferguson JJ, Randall OS (1986) Hemodynamic correlates of arterial compliance. Cath Cardiovasc Diagn 12: 376–380

    Google Scholar 

  23. Safar ME, London GM (1985) Venous system in essential hypertension. Clin Sci 69: 497–504

    Google Scholar 

  24. Echt M, Ddweling J, Gauer OH, Lange L (1974) Effective compliance of the total vascular bed and the intrathoracic compartment derived from changes in central venous pressure induced by volume changes in man. Circ Res 34:61–68

    Google Scholar 

  25. London GM, Safar ME, Simon AC, Alexandre JM, Levenson JA, Weiss YA (1977) Total effective compliance, cardiac output and fluid volumes in essential hypertension. Circulation 57: 995–1000

    Google Scholar 

  26. Wells RE, Denton R (1961) Measurement of viscosity of biologic fluids by cone plate viscometer. J Lab Clin Med 57: 646–656

    Google Scholar 

  27. Chien S (1981) Hemorheology in disease: pathophysiological significance and therapeutic implications. Clin Hemorheology 1: 419–422

    Google Scholar 

  28. Letcher RL, Chien S, Pickering TG, Sealey JE, Laragh JH (1981) Direct relationship between blood pressure and blood viscosity in normal and hypertensive subjects. Am J Med 70:1195–1202

    Google Scholar 

  29. Devereux RB, Drayer JI, Chien S, Pickering TG, Letcher RL, Deyound JL, Sealey JE, Laragh JH (1984) Whole blood viscosity as a determinant of cardiac hypertrophy in systemic hypertension. Am J Cardiol 54: 592–595

    Google Scholar 

  30. Harkness J (1981) Measurement of plasma viscosity. In Lowe GDO, Barbenel JC, Forbes CD (ed) Clinical aspects of blood viscosity and red blood cell deformability. Springer, Berlin Heidelberg New York

    Google Scholar 

  31. Di Minno G, Mancini M (1990) Measuring plasma fibrinogen to predict stroke and myocardial infarction. Arteriosclerosis 8:1–7

    Google Scholar 

  32. Bohlen HG (1986) Localisation of vascular resistance changes during hypertension. Hypertension 8: 181–183

    Google Scholar 

  33. Hof RP, Tapparelli C, Weinstein DB (1990) Hemodynamic, antivasoconstrictor and antiatherosclerotic effect of calcium antagonists in animal models of atherosclerosis. J Cardiovasc Pharmacol 15 [Suppl 1]: s7-s12

    Google Scholar 

  34. Jackson ChL, Bush RC, Bowyer DE (1989) Mechanism of antiatherogenic action of calcium antagonists. Arterosclerosis 80: 17–26

    Google Scholar 

  35. Bound MG, Wilmoth SK, Enevold GL, Stockland HL (1989) Detection and monitoring of asymptomatic atherosclerosis in clinical trials. Am J Med 86 [Suppl 4A]: 33–36

    Google Scholar 

  36. Sjöberg T, Andersson K-E, Norgren L, Steen S (1987) Comparative effects of some calcium-channel blockers on human peripheral arteries and veins. Acta Physiol Scand 130: 419–427

    Google Scholar 

Download references

Author information

Affiliations

  1. Department of Medicine I, University of Göteborg Sahlgrenska Hospital, 41345, Göteborg, Sweden

    M. Wysocki, B. Persson, U. Bagge & O. K. Andersson

Authors
  1. M. Wysocki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. Persson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. U. Bagge
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. O. K. Andersson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Wysocki, M., Persson, B., Bagge, U. et al. Flow resistance and its components in hypertensive men treated with the calcium antagonist isradipine. Eur J Clin Pharmacol 43, 463–468 (1992). https://doi.org/10.1007/BF02285086

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02285086

Key words

  • Hypertension, Isradipine
  • haemorheology, haemodynamics, calcium antagonist