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European Journal of Clinical Pharmacology

, Volume 43, Issue 6, pp 661–662 | Cite as

Single-dose and steady-state pharmacokinetics of sabeluzole in senile dementia of Alzheimer type patients

  • P. P. De Deyn
  • V. Van de Velde
  • W. Verslegers
  • J. Saerens
  • B. A. Pickut
  • B. Clincke
  • R. Woestenborghs
  • A. Van Peer
Short Communications

Summary

The single- and repeated-dose pharmacokinetics of sabeluzole have been determined in six elderly patients with [senile] dementia of the Alzheimer type.

After a single oral dose of 10 mg sabeluzole, the peak plasma concentration was attained at 1 to 4 h; it averaged 42 ng·ml−1. On repeated dosing (10 mg b. d.), steady-state was virtually attained after 3 days of treatment. Steadystate mean trough and peak plasma concentrations fluctuated between 53 and 94 ng·ml−1. The mean terminal half-life after a single dose and at steady-state was of the order of 33 h.

Sabeluzole was well tolerated and at the end of treatment, no systematic changes in blood haematology, biochemistry or urinalysis were seen.

Keywords

Sabeluzole, Alzheimer pharmacokinetics, single and repeated dosing, (senile) dementia, tolerability 

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • P. P. De Deyn
    • 1
  • V. Van de Velde
    • 2
  • W. Verslegers
    • 1
  • J. Saerens
    • 1
  • B. A. Pickut
    • 1
  • B. Clincke
    • 2
  • R. Woestenborghs
    • 2
  • A. Van Peer
    • 2
  1. 1.Department of Neurology, General Hospital Middelheim and Department of NeurochemistryBorn-Bunge Foundation U. I. A.AntwerpBelgium
  2. 2.Department of Drug Metabolism and PharmacokineticsJanssen Research FoundationBeerseBelgium

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