European Journal of Clinical Pharmacology

, Volume 43, Issue 6, pp 647–650 | Cite as

Pharmacokinetics and effects of atrial natriuretic factor during hypothermic cardiopulmonary bypass

  • M. Hynynen
  • K. T. Olkkola
  • R. Palojoki
  • I. Tikkanen
  • E. Fyhrquist


The pharmacokinetics of a bolus dose of synthetic atrial natriuretic factor (ANF) 50 μg and its effects on urine output, blood pressure and plasma renin activity have been studied in 5 patients undergoing hypothermic cardiopulmonary bypass for cardiac surgery.

The half-lives of the fast and slow components were 2.4 min and 14.2 min, respectively. The volume of the central compartment was 16.71 and the volume of distribution at steady-state was 38.91. The total plasma clearance was 3.81-min−1.

ANF significantly increased urine output and decreased blood pressure, but it did not affect plasma renin activity.

Key words

Atrial natriuretic factor cardiac surgery, cardiopulmonary bypass, hypothermia, pharmacodynamics, pharmacokinetics 


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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • M. Hynynen
    • 1
  • K. T. Olkkola
    • 1
    • 2
  • R. Palojoki
    • 1
  • I. Tikkanen
    • 3
  • E. Fyhrquist
    • 3
  1. 1.Departments of AnaesthesiaHelsinki University Central HospitalHelsinkiFinland
  2. 2.Department of Clinical PharmacologyHelsinki University Central HospitalHelsinkiFinland
  3. 3.Fourth Department of MedicineHelsinki University Central HospitalHelsinkiFinland

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