European Journal of Clinical Pharmacology

, Volume 43, Issue 6, pp 591–595 | Cite as

Salmeterol protects against hyperventilation-induced bronchoconstriction over 12 hours

  • D. Nowak
  • R. Jörres
  • K. F. Rabe
  • M. Lüthke
  • J. Wieβmann
  • H. Magnussen


To study the dose-response relationship of salmeterol for protection against a naturally occurring stimulus, isocapnic hyperventilation tests of cold air were done in 16 asthmatic patients. The subjects inhaled either 50 μg salmeterol, salbutamol 200 μg, or placebo in a double-blind, randomised, cross-over study. The FEVI was measured prior to medication and the provocative ventilation (PV20) required to induce a 20 % fall in FEV1 was calculated by linear interpolation from ventilation-response curves obtained 0.5, 4, 8, and 12 h after medication. Following salbutamol, the mean FEV1 were 4.11, 3.89, 3.58, and 3.551, with a significant difference from placebo up to 4 h. Following salmeterol, mean FEV1 values were 3.95, 4.10, 3.93, and 3.881, with a significant difference from placebo up to 12 h. The mean PV20FEV1 after salbutamol was 78.8, 58.5, 52.7, and 48.41·min−1, the 0.5 h value being significantly different from placebo. After salmeterol, the mean PV20FEV1 values were 84.6, 82.5, 67.8, and 65.81·min−1, with a significant difference from placebo up to 12 h.

We conclude that, besides its long-lasting bronchodilating effect, salmeterol protects against hyperventilation-induced bronchoconstriction for at least 12 h.

Key words

Salmeterol, Asthma bronchodilation, hyperventilation-induced bronchoconstriction 


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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • D. Nowak
    • 1
  • R. Jörres
    • 1
  • K. F. Rabe
    • 1
  • M. Lüthke
    • 1
  • J. Wieβmann
    • 2
  • H. Magnussen
    • 1
  1. 1.Center for Pneumology and Thoracic SurgeryGrosshansdorf HospitalHamburgGermany
  2. 2.Department of Internal MedicineMedical UniversityLübeckGermany

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