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Exertion ulcers in the rat

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Abstract

Gastric ulcers were produced in rats by forced muscular exercise (“exertion ulcers”). These ulcers were multiple, bleeding, located in the corpus, consisted of hemorrhagic necrosis of the mucosa, and could easily be counted. The animals were fasted overnight prior to exertion. Female rats were more sensitive than males to this type of ulcer. Agents known to reduce gastric acidity (anti-cholinergics, antacids, mercuric acetate) prevented their formation, as did prednisolone. Neither adrenalectomy nor administration of desoxycorticosterone affected these ulcers. During exertion, volume and acidity of gastric juice were reduced. Although the pathogenesis of these ulcers remains to be elucidated, the following chain of events is offered as a hypothesis: Exertion (severe stress) → vascular shock → impairment of gastric circulation → gastric anoxia → decreased resistance to autodigestion → ulcers.

Since exertion ulcers can be graded quantitatively (incidence, severity, and number of ulcers are expressed as such, and also are combined as an “ulcer index”), and are prevented by antiulcer drugs on a dose-dependent basis, this technic is proposed as an assay for antiulcer agents. Its main advantages are rapidity (2 hr and 45 min), simplicity, reproducibility and quantitation.

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Authors and Affiliations

  1. From the Experimental Biology Division, The Upjohn Company, Kalamazoo, Mich

    André Robert MD, PhD, J. I. Northam MA, J. E. Nezamis BS & J. P. Phillips BS

Authors
  1. André Robert MD, PhD
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  2. J. I. Northam MA
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  3. J. E. Nezamis BS
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  4. J. P. Phillips BS
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Robert, A., Northam, J.I., Nezamis, J.E. et al. Exertion ulcers in the rat. Digest Dis Sci 15, 497–507 (1970). https://doi.org/10.1007/BF02283881

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