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Attempts to produce achlorhydria in dogs by repeated gastric injury with heat and cold

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Abstract

Up to 21 gastric “freezing” treatments were given to 11 dogs with gastric fistulas and up to 11 heating treatments were given to 8 dogs in an attempt to induce sustained hypochlorhydria. A profound and sustained reduction of histamine response occurred in only 1 dog. Although endoscopic and histologic evidence of repeated and severe mucosal damage was observed, recovery occurred quickly. The recovery was quicker and more complete with heating than with freezing. The gastric mucosa of the dog has remarkable ability to recover from repeated, severe thermal injury.

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Authors and Affiliations

  1. From the Medical Service, Veterans Administration, Hines, Ill

    George T. Perry MD, Margaret S. Littman MD &  Armand Littman MD

  2. the Department of Medicine, University of Illinois College of Medicine, Chicago, Ill

    George T. Perry MD, Margaret S. Littman MD &  Armand Littman MD

Authors
  1. George T. Perry MD
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  2. Margaret S. Littman MD
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  3. Armand Littman MD
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Additional information

Supported in part by USPHS grant AM 07262.

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Perry, G.T., Littman, M.S. & Littman, A. Attempts to produce achlorhydria in dogs by repeated gastric injury with heat and cold. Digest Dis Sci 15, 427–436 (1970). https://doi.org/10.1007/BF02283870

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  • DOI: https://doi.org/10.1007/BF02283870

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