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Increased susceptibility to proteolytic action of gastric superficial mucosa after sialic acid release

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Abstract

The purpose of this investigation was to find out (1) whether a pH dependent, chemical extraction, of sialic acid might occur in the superficial mucous layer of gastric mucosa as a result of prolonged states of hyperacidity of gastric juice and (2) whether the release of sialic acid could induce increased susceptibility of this mucin to proteolytic action. We have demonstrated that the superficial layer of gastric mucosa in a group of selected normoacid subjects exhibits an important resistance to pepsin, trypsin, and papain digestion. This resistance decreases after sialidase incubation and especially after mild acid hydrolysis in 0.02 N HCl at pH 1.6. On the other hand, the superficial layer of gastric mucosa in a group of selected hyperacid subjects exhibits both an important loss of mucin basophilia and an augmented susceptibility to prteolytic action.

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Authors and Affiliations

  1. From the Institute of Internal Medicine, the Academy of Medical Sciences, Bucharest, Rumania

    C. Velican MD, Doina Velican MD, N. Marcus MD & S. Tacorian MD

  2. the Medical Clinic of the Vasile Roaita Hospital, Bucharest, Rumania

    C. Velican MD, Doina Velican MD, N. Marcus MD & S. Tacorian MD

Authors
  1. C. Velican MD
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  2. Doina Velican MD
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  3. N. Marcus MD
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  4. S. Tacorian MD
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Additional information

The authors are indebted to Ernestina Ponova for skilled technical assistance and to Louisa Schioiu for the statistical treatment of the results.

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Velican, C., Velican, D., Marcus, N. et al. Increased susceptibility to proteolytic action of gastric superficial mucosa after sialic acid release. Digest Dis Sci 15, 413–418 (1970). https://doi.org/10.1007/BF02283867

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  • DOI: https://doi.org/10.1007/BF02283867

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