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Chemistry of Heterocyclic Compounds

, Volume 36, Issue 2, pp 185–189 | Cite as

Synthesis of fused systems containing an angular nitrogen atom from substituted 2-benzyl-4-hydrazinopyridimines

  • G. G. Danagulyan
  • L. G. Sahakyan
  • G. A. Panosyan
Article

Abstract

The condensation of substituted 2-benzyl-4-hydrazinopyrimidines with phenylpyruvic acid gave the corresponding hydrazones, which cyclize upon the action of POCl, to give derivatives of pyrimido[6,1-c][1,2,4]-triazine. The substituted 2-benzylpyrimidinylhydrazides of some carboxylic acids react with POCl, to give 1,2,4-triazolo[4,3-c]pyrimidines. The reaction of 7-benzyl-5-methyl-l-phenyl-1,2,4-triazolo[2,3-c]pyrimidine with sodium ethylate leads to rearrangement and formation of 7-benzyl-5-methyl-2-phenyl-1,2,4-triazolo[2,3-c]pyrimidine.

Keywords

hydrazides hydrazone Dimroth rearrangement pyrimidine pyrimido[6,1-c][1,2,4]triazine 1,2,4-triazolo[2,3-c]pyrimidine 1,2,4-triazolo[4,3-c]pyrimidine 

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Copyright information

© Kluwer Academic/Plenum Publisher 2000

Authors and Affiliations

  • G. G. Danagulyan
    • 1
  • L. G. Sahakyan
    • 1
  • G. A. Panosyan
    • 2
  1. 1.Yerevan Institute of the National EconomyYerevanRepublic of Armenia
  2. 2.Center for the Study of Molecular StructureNational Academy of Sciences of the Republic of ArmeniaYerevanRepublic of Armenia

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