Skip to main content
SpringerLink
Log in

Treatment of rheumatoid arthritis with anti CD4 monoclonal antibody. Open study of 25 patients with the B-F5 clone

  • Originals
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Summary

Twenty-five defined severe RA patients (pts) (17 F, 8 M) were treated in an open study with a CD4 murine monoclonal antibody (Mab) (B-F5 clone, IgG1). Mab's daily dose was 10 mg (1 pt), 15 mg (2 pts), 20 mg (17 pts), 30 mg (4 pts) and 50 mg (1 pt) for 10 days. Tolerance was fair. Clinical improvement occurred during treatment period or within the first month in all but 2 patients, irrespective of Mab dosage. Improvement duration was variable (1 to 12 months), half of the patients still show signs of improvement at month 4. Biological parameters (CRP) improved parallel to the clinical. At day 180, 25% of the patients showed a reduction of 50% or more of the initial CRP values. There is no modification of RF titers, renal and hepatic parameters. Sequential evaluation showed a decrease of B, TCD3, CD4, CD8 lymphocytes and monocytes two hours after Mab infusion and return to baseline in 20 hours. Xenogenic immunization occurred in 6 patients without influence upon clinical response. These modifications are moderate and transient and do not account for the more prolonged effect in some cases, nor do they offer any prediction of further clinical response.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kingsley, G., Pitzalis, C., Panayi, G.S. Immunogenetic and cellular immune mechanisms in rheumatoid arthritis: relevance to new therapeutic strategies. Br J Rheumatol 1990, 29, 58–64.

    Article  CAS  PubMed  Google Scholar 

  2. Lipsky, P.E., Ziff, M. Inhibition of human helper T cell function in vitro by D-penicillamine and CuS04. J Clin Invest 1980, 65, 1069.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Dougados, M., Awada, H., Amor, B. Cyclosporin in rheumatoid arthritis: a double-blind placebo controlled study in 52 patients. Ann Rheum Dis 1988, 47, 127–133.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Paulus, H.E., Machleder, H.I., Levine, S., Yu, D.T.Y., MacDonald, N.S. Lymphocyte involvement in rheumatoid arthritis. Studies during thoracic duct drainage. Arthritis Rheum 1990, 20, 1249–1262.

    Article  Google Scholar 

  5. Soden, M., Hassan, J., Scott, D.L. Lymphoid irradiation in intractable rheumatoid arthritis. Arthritis Rheum 1989, 32, 523–530.

    Article  CAS  PubMed  Google Scholar 

  6. Sany, J. Immunological treatment of rheumatoid arthritis. Clin Exp Rheumatol 1990, 8 (suppl. 5), 81–88.

    PubMed  Google Scholar 

  7. Riethmuller, G., Reiter, C., Kakavand, B., Schattenkirchner, M., Kruger, K., Eisenburg, J., Rieber, E.P. Immunomodulation by monoclonal antibodies directed against cell adhesion molecules: a special case for CD4 monoclonal antibodies. Eur J Rheumatol Inflam 1991, 11, 177–181.

    Google Scholar 

  8. Kingsley, G. Monoclonal antibody treatment of rheumatoid arthritis. Br J Rheumatol 1991, 30 (suppl. 2), 33–35.

    PubMed  Google Scholar 

  9. Horneff, G., Burmester, G.R., Emmrich, F., Kalden, J.R. Treatment of rheumatoid arthritis with an anti CD4 monoclonal antibody. Arthritis Rheum 1991, 34, 129–140.

    Article  CAS  PubMed  Google Scholar 

  10. Herzog, C., Walker, C., Muller, W., Rieber, P., Reiter, C., Riethmuller, G., Wassmer, P., Stockinger, H., Madic, O., Pichler, W.J. Anti CD4 antibody treatment of patients with rheumatoid arthritis: I. Effect on clinical course and circulating T cells. J Autoimmunity 1989, 2, 627–642.

    Article  CAS  Google Scholar 

  11. Reiter, C., Kawavand, B., Rieber, E.P., Schattenkirchner, M., Riethmuller, G., Kruger, K. Treatment of rheumatoid arthritis with monoclonal CD4 antibody M-T151. Arthritis Rheum 1991, 34, 525–536.

    Article  CAS  PubMed  Google Scholar 

  12. Goldberg, D., Chatenoud, L., Morel, P., Boitard, C., Revillard, J.P., Bertoye, P., Bach, J.F., Menkes, C.J. Preliminary trial for an anti CD4 monoclonal antibody in rheumatoid arthritis. Arthritis Rheum 1990, 33, S 153.

    Article  Google Scholar 

  13. Wendling, D., Wijdenes, J., Racadot, E., Morel-Fourrier, B. Therapeutic use of monoclonal anti CD4 antibody in rheumatoid arthritis. J Rheumatol 1991, 18, 325–327.

    CAS  PubMed  Google Scholar 

  14. Arnett, F.C., Edworthy, S.M., Bloch, D.A., McShane, D.J., Fries, J.F., Cooper, N.S., Healey, L.A., Kaplan, S.R., Liang, M.H., Luthra, H.S., Medsger, T.A., Mitchell, D.M., Neustadt, D.H., Pinals, R.S., Schaller, J.G., Sharp, J.T., Wilder, R.L., Hunder, G.G. The American Rheumatism Association 1987 revised criteria for classification of rheumatoid arthritis. Arthritis Rheum 1988, 31, 315–324.

    Article  CAS  PubMed  Google Scholar 

  15. Steinbrocker, O., Taaeger, C.H., Batterman, R.C. Therapeutic criteria in rheumatoid arthritis. JAMA 1949, 140, 659–662.

    Article  CAS  Google Scholar 

  16. Ritchie, D.M., Boyle, J.A., McInnes, J.M., Jasani, M.K., Dalakos, T.G., Grieveson, P., Buchanan, W.W. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Q J Med 1968, 147, 393–406.

    Google Scholar 

  17. Racadot, E., Wijdenes, J., Wendling, D. Immunological followup of 17 patients with rheumatoid arthritis treated in vivo with an anti T CD4 + monoclonal antibody (B-F5). Clin Exp Rheumatol 1992, 10, 365–374.

    CAS  PubMed  Google Scholar 

  18. Pinals, R.S., Masi, A.T., Larsen, R.A. Preliminary criteria for clinical remission in rheumatoid arthritis. Arthritis Rheum 1981, 24, 1308–1315.

    Article  CAS  PubMed  Google Scholar 

  19. Reiter, C., Van der Lubbe, P.A., Breedveld, F.C., Daddona, P., Kruger, K., Kakavand, B., Riethmuller, G. Chimeric monoclonal CD4 antibody induces a long lasting CD4 cell depletion in rheumatoid arthritis patients. Arthritis Rheum 1991, 34, S91.

    Article  Google Scholar 

  20. Van der Lubbe, Reiter, C., Riethmuller, G., Sanders, M.E., Breedveld, F.C.. Treatment of rheumatoid arthritis with chimeric CD4 monoclonal antibody. Arthritis Rheum 1991, 34, S89.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Service de Rhumatologie, Hôpital J. Minjoz, CHRU, F. 25030, Besançon, France

    D. Wendling

  2. Laboratoire d'Immunocytologie, Centre Régional de Transfusion Sanguine, F. 25020, Besançon, France

    E. Racadot

  3. Laboratoire des Anticorps Monoclonaux, Centre Régional de Transfusion Sanguine, F. 25020, Besançon, France

    B. Morel-Fourrier & J. Wijdenes

Authors
  1. D. Wendling
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Racadot
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. Morel-Fourrier
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. Wijdenes
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wendling, D., Racadot, E., Morel-Fourrier, B. et al. Treatment of rheumatoid arthritis with anti CD4 monoclonal antibody. Open study of 25 patients with the B-F5 clone. Clin Rheumatol 11, 542–547 (1992). https://doi.org/10.1007/BF02283116

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02283116

Key Words

Search

Navigation