Clinical Rheumatology

, Volume 11, Issue 4, pp 492–497 | Cite as

Prevention of post-menopausal bone loss with 1α-hydroxy vitamin D3 a three-year prospective study

  • J. M. Pouilles
  • F. Tremollieres
  • C. Ribot


An open and controlled prospective study was used to assess the preventive efficiency of 1α-hydroxy vitamin D3 (1α (OH) Vit. D3) on post-menopausal vertebral bone loss. Of the 36 patients included in the study, 25 completed two years of treatment with 1 μg/day of 1α (OH) Vit. D3 and 500 mg of calcium. The vertebral bone mineral density measured by dual photon absorptiometry did not vary in the treated group, whereas it decreased significantly in the control group at the end of the 2 years. At two years, withdrawal of treatment led to a signficant bone loss, whereas bone mass remained stable in a subgroup of patients who underwent a third year of treatment with 1α (OH) Vit. D3. Overall, tolerance was satisfactory. However, urinary calcium increased significantly during treatment and one third of the patients developed hypercalciuria ≥7.5 mmoles/24 h. No variation in either serum calcium or creatinine levels was noted. These results indicate that 1α (OH) Vit. D3 could be useful in preventing post-menopausal bone loss provided it was complemented by regular monitoring of urinary calcium excretion.

Key words

Osteoporosis Prevention 1α-Hydroxy Vitamin 


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Copyright information

© Acta Medica Belgica 1992

Authors and Affiliations

  • J. M. Pouilles
    • 1
  • F. Tremollieres
    • 1
  • C. Ribot
    • 1
  1. 1.Service d'Endocrinologie- U.F.Maladies Osseuses et Métaboliques-CHU PurpanToulouse CedexFrance

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