Synthesis of two peptides of α-bungarotoxin and the participation of the amino acid residue Trp-28 of the neurotoxin in the antigenicity of the molecule
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Using the method of solid-phase peptide synthesis, two peptides have been synthesized, one of which corresponds to the central ring structure of α-bungarotoxin (α-BTX), while the second has in position 28 a Gly residue in place of the Trp in the first peptide, and their interrelationship with antitoxin antibodies has been investigated. It has been shown that the amino acid residue Trp-28 of α-BTX, which is the contact residue in binding with the acetylcholine receptor, also participates directly in binding with the active centers of antibodies to α-BTX.
KeywordsPeptide Organic Chemistry Amino Acid Residue Acetylcholine Active Center
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