Chemistry of Natural Compounds

, Volume 33, Issue 4, pp 485–487 | Cite as

Synthesis of two peptides of α-bungarotoxin and the participation of the amino acid residue Trp-28 of the neurotoxin in the antigenicity of the molecule

  • B. Z. Dolimbek
  • M. Z. Atassi
Article
  • 47 Downloads

Abstract

Using the method of solid-phase peptide synthesis, two peptides have been synthesized, one of which corresponds to the central ring structure of α-bungarotoxin (α-BTX), while the second has in position 28 a Gly residue in place of the Trp in the first peptide, and their interrelationship with antitoxin antibodies has been investigated. It has been shown that the amino acid residue Trp-28 of α-BTX, which is the contact residue in binding with the acetylcholine receptor, also participates directly in binding with the active centers of antibodies to α-BTX.

Keywords

Peptide Organic Chemistry Amino Acid Residue Acetylcholine Active Center 

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Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • B. Z. Dolimbek
    • 1
  • M. Z. Atassi
    • 2
  1. 1.A. S. Sadykov Institute of Bioorganic ChemistryAcademy of Sciences of the Republic of UzbekistanTashkent
  2. 2.Baylor College of MedicineHoustonUSA

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