Chemistry of Natural Compounds

, Volume 33, Issue 4, pp 485–487 | Cite as

Synthesis of two peptides of α-bungarotoxin and the participation of the amino acid residue Trp-28 of the neurotoxin in the antigenicity of the molecule

  • B. Z. Dolimbek
  • M. Z. Atassi


Using the method of solid-phase peptide synthesis, two peptides have been synthesized, one of which corresponds to the central ring structure of α-bungarotoxin (α-BTX), while the second has in position 28 a Gly residue in place of the Trp in the first peptide, and their interrelationship with antitoxin antibodies has been investigated. It has been shown that the amino acid residue Trp-28 of α-BTX, which is the contact residue in binding with the acetylcholine receptor, also participates directly in binding with the active centers of antibodies to α-BTX.


Peptide Organic Chemistry Amino Acid Residue Acetylcholine Active Center 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    B. M. Coti-Tronconi, K. E. McLane, M. A. Raftery, S. A. Grando, and M. Pia Protti, Crit. Rev. Biochem. Mol. Biol.,29, No. 2, 69 (1994).Google Scholar
  2. 2.
    M. Z. Atassi, B. Mulac-Jericevic, T. Yokoi, and T. Manshouri, Fed. Proc.,47, No. 8, 2538 (1987).Google Scholar
  3. 3.
    R. H. Fairclough, J. Finer-Moore, R. A. Love, D. Kristofferson, P. L. Desmueles, and R. M. Stroud, Cold Spring Harbor Symp. Quant. Biol.,48, 9 (1983).Google Scholar
  4. 4.
    M. Z. Atassi, Immunochemistry,15, No. 12, 909 (1978).Google Scholar
  5. 5.
    R. B. Merrifield, J. Am. Chem. Soc.,85, 2149 (1963).Google Scholar
  6. 6.
    D. A. Agard and R. M. Stroud, Acta Crystallogr.,38A, 186 (1982).Google Scholar
  7. 7.
    B. Z. Dolimbek and M. Z. Atassi, J. Protein Chem., No. 5, 490 (1994).Google Scholar

Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • B. Z. Dolimbek
    • 1
  • M. Z. Atassi
    • 2
  1. 1.A. S. Sadykov Institute of Bioorganic ChemistryAcademy of Sciences of the Republic of UzbekistanTashkent
  2. 2.Baylor College of MedicineHoustonUSA

Personalised recommendations