Digestive Diseases and Sciences

, Volume 41, Issue 3, pp 543–548 | Cite as

Effect of cisapride on gallbladder emptying and plasma CCK in normal and vagotomized human subjects

  • R. Patankar
  • M. M. Ozmen
  • A. Sanderson
  • C. D. Johnson
Pancreatic And Biliary Disorders

Abstract

Previous studies have provided conflicting results on the effects of cisapride on gallbladder emptying in response to a meal. We studied six volunteers and six patients after a truncal vagotomy in a double-blind, placebo-controlled, prospectively randomized study using 10 mg cisapride four times a day for three days. Gallbladder volume was quantitated using ultrasonography, and plasma CCK levels were measured with a sensitive and specific radioimmunoassay using the DINO antibody before and for 90 min after a fatty, mixed meal. Plasma CCK levels were unchanged after treatment with cisapride in both groups. No prokinetic effect was observed on the gallbladder either in normal subjects or vagotomized patients. Paradoxically, residual volume (RV) was increased in the vagotomized patients after treatment with cisapride: RV cisapride 7.1 (4.1–15.9) ml, RV placebo 5.1 (3.8–14) ml,P<0.05. Further work is required to clarify the mechanisms of action of cisapride on the gallbladder and the sphincter of Oddi. The use of cisapride during litholytic therapy may impair gallbladder emptying and delay stone clearance.

Key words

cisapride gallbladder cholecystokinin 

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Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • R. Patankar
    • 1
  • M. M. Ozmen
    • 1
  • A. Sanderson
    • 1
  • C. D. Johnson
    • 1
  1. 1.From the University Surgical Unit and Department of RadiologySouthampton General HospitalSouthamptonUK

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