Clinical Autonomic Research

, Volume 6, Issue 3, pp 163–169 | Cite as

Measurement of myocardial accumulation of123I-metaiodobenzylguanidine for studying cardiac autonomic neuropathy in diabetes mellitus

  • M. Mäntysaari
  • J. Kuikka
  • J. Mustonen
  • K. Tahvanainen
  • E. Vanninen
  • E. Länsimies
  • M. Uusitupa
Research Paper


The association of myocardial123I-metaiodobenzylguanidine (MIBG) accumulation and autonomic neuropathy, as well as factors known to affect autonomic nervous function, were studied in a group of 12 diabetic patients representing different degrees of autonomic failure. The early myocardial uptake phase of123I-MIBG was measured by calculating the peak net influx rate for the first 30 min after the123I-MIBG injection and by single photon emission computed tomography (SPECT) imaging 1 h after the injection. The retainment of123I-MIBG in the myocardium was measured using SPECT imaging 6 h after the injection, and myocardial uptake and the myocardium/liver uptake ratio were calculated. The 6-h myocardium/liver uptake ratio of123I-MIBG was significantly (p<0.05) lower in the diabetic patients with clinically evident autonomic neuropathy compared with those without autonomic neuropathy. Geater body mass index was associated with lower peak net influx rate and 1-h myocardial uptake of123I-MIBG, and greater diastolic blood pressure was associated with lower 1-h myocardial uptake of123I-MIBG, whether or not the patients had diabetic autonomic neuropathy. In conclusion, reduction in the 6-h myocardium/liver uptake ratio of123I-MIBG is related to diabetic autonomic neuropathy. Because the early123I-MIBG accumulation in myocardium is reduced in diabetic patients with greater body mass index and diastolic blood pressure, irrespective of autonomic neuropathy, our results encourage the use of the late myocardial accumulation of123I-MIBG for studying sympathetic neuropathy in the diabetic heart.


autonomic nervous function cardiac function diabetes mellitus 123I-MIBG exercise test 


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Copyright information

© Rapid Science Publishers 1996

Authors and Affiliations

  • M. Mäntysaari
    • 5
  • J. Kuikka
    • 1
  • J. Mustonen
    • 2
  • K. Tahvanainen
    • 4
  • E. Vanninen
    • 1
  • E. Länsimies
    • 1
  • M. Uusitupa
    • 3
  1. 1.Department of Clinical PhysiologyKuopio University HospitalKuopio
  2. 2.Department of MedicineKuopio University HospitalKuopio
  3. 3.Clinical NutritionKuopio University HospitalKuopio
  4. 4.Department of Clinical PhysiologyTampere University HospitalTampereFinland
  5. 5.Research Institute of Military MedicineHelsinkiFinland

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