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Hyperhidrosis and sympathetic skin response in chronic alcoholic patients

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Abstract

Palmoplantar hyperhidrosis is frequently observed in patients with a clinical history of chronic abnormal alcoholic intake. It can be related to peripheral or central mechanisms such as abnormal spontaneous activity in peripheral damaged fibres; receptor hypersensitivity; compensatory incremented activity in segmentary anhidrosis; or impairment of central sweat control. With the aim of quantifying this phenomenon and of identifying its possible origin, sympathetic skin response (SSR) analysis was performed in 20 chronic alcoholic patients with clinical diffuse acral hyperhidrosis, compared with 30 normal subjects and 2 patients affected by primary palmoplantar hyperhidrosis (PPH). SSRs were recorded by disc electrodes place on the hands and feet, simultaneously. At the hand level two recording sites were selected: palm-dorsum proximally and ventral-dorsal tip of the third finger distally. Attention was paid to the number of SSR after a single endogenous or exogenous stimulus. The alcoholic patients were divided into two groups, with and without mild polyneuropathy. Both patient groups showed synchronous SSR at recording sites, with the same pattern and the normal delay between upper and lower arms. In the control group one response was generally related to a single stimulus; if more responses were elicited an evident adaptation was shown; in the two groups of patients an increase of the waves was observed in all the recording sites without any adaptation. The SSR profile described in alcoholic patients was observed also in PPH. The pattern of SSR waves in alcoholic patients seems to suggest a possible central origin of this type of hyperhidrosis.

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References

  1. Low PA, Walsh JC, Huang CY, McLeod JG. The sympathetic nervous system in alcoholic neuropathy — a clinical and pathological study.Brain 1975; 98:357–364.

    Google Scholar 

  2. Novak DJ, Victor M. The vagus and sympathetic nerves in alcoholic neuropathy.Arch Neurol 1974; 30:273–284.

    Google Scholar 

  3. Monforte R, Estruch R, Valls-Solé J, Nicolas JJ, Villalta J, Urbano-Marquez A. Autonomic and peripheral neuropathies in patients with chronic alcoholism.Arch Neurol 1995; 52:45–51.

    Google Scholar 

  4. Valls-Solθ J, Monforte R, Estruch R. Abnormal sympathetic skin response in alcoholic subjects.J Neurol Sci 1991; 102:233–237.

    Google Scholar 

  5. Navarro X, Miralles R, Espadaler JE, Rubiés-Prat J. Comparison of sympathetic sudomotor and skin responses in alcoholic neuropathy.Muscle Nerve 1993; 16:404–407.

    Google Scholar 

  6. Low PA. Sudomotor function and dysfunction. In: Asbury AK, McKhann GM, McDonald WI, eds.Diseases of the Nervous System: Clinical Neurobiology. Philadelphia: Saunders Company; 1992:479–1166.

    Google Scholar 

  7. Shahani BT, Day TJ, Cros D, Khalil N, Kneebone CS. Sympathetic skin response—a method of assessing unmyelinated axon dysfunction in peripheral neuropathies.J Neurol Neurosurg Psychiat 1984; 47:536–542.

    Google Scholar 

  8. Delius W, Hagbarth KE, Hongell A, Wallin G. Maneoeuvres affecting sympathetic outflow in human skin nerves.Acta Physiol Scand 1972; 84:177.

    Google Scholar 

  9. Wallin G. Intraneural recording and autonomic function in man. The effect of mental stimuli. In: Bannster R, ed.Autonomic Failure. Oxford University Press: Oxford; 1984:39–40.

    Google Scholar 

  10. Duncan G, Johnson RH, Lambie DG, Whiteside EA. Evidence of vagal neuropathy in chronic alcoholics.Lancet 1980; 2:1053–1056.

    Google Scholar 

  11. Low PA, Walsh JC, Huang CY, McLeod JG. The sympathetic nervous system in alcoholic neuropathy. A clinical and pathological study.Brain 1975; 98:357–364.

    Google Scholar 

  12. Rabin BA, Carter K, Chaudhry V. Hyperhidrosis: clinical and electrophysiological characteristics of two patients.Muscle Nerve 1994; 9:1117.

    Google Scholar 

  13. Fealey RD. The Thermoregulatory Sweat Test. In: Low PA, ed.Clinical Autonomic Disorders. Little, Brown and Company: Boston; 1993;217–229.

    Google Scholar 

  14. Kennedy WR, Sakuta M, Sutherland D, Goetz FC. The sweating deficiency in diabetes mellitus: methods of quantification and clinical correlation.Neurology 1984; 34:758–763.

    Google Scholar 

  15. Kennedy WR, Sakuta M, Sutherland D, Goetz FC. Quantification of the sweating deficiency in diabetes mellitus.Ann Neurol 1984; 15:482–488.

    Google Scholar 

  16. Uncini A, Di Muzio A, Cutarella R, Malatesta G, Lugaresi A. The sympathetic skin response: normal values, elucidation of afferent components and application limits.J Neurol Sci 1988; 87:299–306.

    Google Scholar 

  17. Low PA, Caskey PE, Tuck RR, Fealey RD, Dyck PJ. Quantitative sudomotor axon reflex test in normal and neuropathic subjects.Ann Neurol 1983; 14:573–580.

    Google Scholar 

  18. Nakayama T, Takagi K. Minute pattern of human perspiration observed by a continuously recording method.Jpn J Physiol 1959: 9:359–364.

    Google Scholar 

  19. Bullard RW. Continous recording of sweating rate by resistance hygrometry.J Appl Physiol 1962; 17:735–737.

    Google Scholar 

  20. Nilsson GE. Measurement of water exchange through skin.Med Biol Eng Comput 1977; 15:209–218.

    Google Scholar 

  21. Levy DM, Reid G, Abraham RR, Rowley DA. Assessment of basal and stimulated sweating in diabetes using a direct-reading computerized sudorometer.Diabetic Med 1991; 8:78–81.

    Google Scholar 

  22. Lang E, Forster A, Pfannmuller D, Handwerker HO. Quantitative assessment of sudomotor activity by capacitance hygrometry.Clin Autonom Res 1993; 3:107–115.

    Google Scholar 

  23. Lin TK, Chee E CY, Chen HJ, Cheng MH. Abnormal sympathetic skin response in patients with palmar hyperhidrosis.Muscle Nerve 1995; 18:917–919.

    Google Scholar 

  24. Lefaucheur JP, Fitoussi M, Becquemin JP. Abolition of sympathetic skin responses following endoscopic thoracic sympathectomy.Muscle Nerve 1996; 19:581–586.

    Google Scholar 

  25. Chu EC and Chu NS. Patterns of sympathetic skin response in palmar hyperhidrosis.Clin Autonom Res 1997; 7:1–4.

    Google Scholar 

  26. Schondorf R. The role of the sympathetic skin response in the assesment of autonomic function. In: Low PA, ed.Clinical Autonomic Disorders. Littie, Brown and Company: Boston; 1993: 231–241.

    Google Scholar 

  27. Shaver BA, Brusilow SW, Cooke RE. Origin of the galvanic skin response.Proc Soc Exp Biol NY 1962; 110:559–564.

    Google Scholar 

  28. Ogawa T, Asayama M, ito M. Comparison of sudomotor neural activities between palmar and non-palmar sweating. In: J Sugenoya.Central Mechanism For Sweating (II). Rinsho Noha: Japan; 1990:189–194.

    Google Scholar 

  29. Ogawa T, Sugenoya J. Pulsatile sweating and sympathetic sudomotor activity.Jpn J Physiol 1993; 43:275–289.

    Google Scholar 

  30. Cloward RB. Hyperhidrosis.J Neurosurg 1966; 30:545–551.

    Google Scholar 

  31. Iwase S, Ikeda T, Kitazawa H, Hakusui S, Sugenoya J, Mano T. Altered response in cutaneous sympathetic outflow to mental and thermal stimuli in primary palmoplantar hyperhidrosis.J Auton Nerv Syst 1997; 64:65–73.

    Google Scholar 

  32. Takagi K, Nakayama T. Peripheral effector mechanism of galvanic skin reflex.Jpn J Physiol 1959; 9:1–7.

    Google Scholar 

  33. Kennedy WR, Navarro X. Sympathetic sudomotor function in diabetic neuropathy.Arch Neurol 1989; 46:1182–1186.

    Google Scholar 

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Tugnoli, V., Eleopra, R. & De Grandis, D. Hyperhidrosis and sympathetic skin response in chronic alcoholic patients. Clinical Autonomic Research 9, 17–22 (1999). https://doi.org/10.1007/BF02280692

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