Pharmaceutisch Weekblad

, Volume 8, Issue 6, pp 302–304 | Cite as

Plasma protein binding of drugs

Implications for therapeutic drug monitoring
  • J. J. H. M. Lohman
  • F. W. H. M. Merkus
  • K. H. Rahn
Abstracts of Dutch Ph.D. Theses

Key words

Blood specimen collection Carbamazepine Dialysis Digitoxin Lipolysis Protein binding Therapeutic drug monitoring Ultrafiltration 

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Results were also presented in the following papers

  1. Janknegt R, Lohman JJHM, Hooymans PM, Merkus FWHM. Do evacuated blood collection tubes interfere with therapeutic drug monitoring? Pharm Weekbl [Sci] 1983;5:287–90.Google Scholar
  2. Lohman JJHM, Merkus FWHM, Costongs GMPJ, Hegtermans EPJMH, Hooymans PM. Factors affecting the determination of unbound carbamazepine concentrations in plasma. Pharm Res 1984;I:49.CrossRefGoogle Scholar
  3. Lohman JJHM, Hooymans PM, Verhey MTJM, Koten MLP, Merkus FWHM. Influence of volume shift in equilibrium dialysis to estimate plasma protein binding of drugs. Pharm Res 1984;I:187–8.CrossRefGoogle Scholar
  4. Lohman JJHM, Merkus FWHM, Costongs GMPJ, Hegtermans EPJMH, Hooymans PM. Pitfalls in the determination of unbound carbamazepine concentrations in plasma. Pharm Weekbl [Sci] 1984;6:91–5.Google Scholar
  5. Lohman JJHM, Hooymans PM, Koten MLP, Verhey MTJM, Merkus FWHM. Effect of heparin on digitoxin protein binding. Clin Pharmacol Ther 1985;37:55–60.PubMedGoogle Scholar
  6. Lohman JJHM, Hooymans PM, Merkus FWHM. Digitoxin protein binding in renal dysfunction. Does it matter? [Abstract]. Pharm Weekbl [Sci] 1986;8:163.Google Scholar
  7. Lohman JJHM, Hooymans PM, Koten MLP, Merkus FWHM. Digitoxin protein binding in patients on hemodialysis. In: Erdmann E, Greef K, Skou JC, eds. Cardiac Glycosides 1785–1985. Darmstadt: Steinkopff, 1986:329–35.Google Scholar

Copyright information

© Bohn, Scheltema & Holkema 1986

Authors and Affiliations

  • J. J. H. M. Lohman
    • 3
  • F. W. H. M. Merkus
    • 1
  • K. H. Rahn
    • 2
  1. 1.Leiden
  2. 2.Maastricht
  3. 3.Department of Clinical PharmacyHospital of SittardSittardThe Netherlands

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