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The clinical use of orally administered47Ca for the investigation of intestinal calcium absorption

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Abstract

Intestinal calcium absorption was measured by the oral administration of calcium47 (in milk as a carrier) to 15 normals and 30 patients and by following the blood concentration at two hours, the twenty four hour urine excretion and cumulative faecal excretion of the isotope. Simultaneous calcium balances allowed an estimate of calcium absorption to be made and this correlated with the blood and faecal data once an allowance was made for the endogenous secretion. This was found to be highly variable, mean values in the patients being 300 mg/24 hours. A slow type of intestinal absorption was found in the osteoporotic group of patients.

Résumé

L'absorption intestinaledu calcium a été mesurée par voix buccale en donnant du calcium47 (dans du lait) à 15 personnes saines et 30 malades et en suivant la concentration du sang après deux heures, excrétion des urines de vingt quatre heures et l'excrétion accumulée des selles, de l'isotope.

Des doses simultanées du calcium nous a permis d'evaluer l'absorption du calcium et cela est correlatif avec la data du sang et des selles, faite après une deduction de la secretion de l'endogine.

On a trouvé que cela ete trop varie, les termes moyens était chez les malades 300 mg/24 heures. On a trouve une absorption intestinale leute, chez les malades du groupe osteoporotique.

Zusammenfassung

Kalziumaufnahme im Darm wurde gemessen durch Einnehmen von Kalzium47 (in Milch als Träger) von 15 “Normalen” und 30 Patienten, und durch verfolgen von Blutkonzentration nach 2 Std, eine 24 Std Urinausscheidung, das Ansammeln von Isotop in Stuhlexkrementen.

Gleichzeitig erlaubte Kalziumausgleich einen Überschlag in Kalziumaufnahme zu machen und dies stand im Zusammenhang mit Blut- und Stuhlergebnissen nach dem Drüsensekret (endogenous) zuvor in Betracht gezogen wurde.

Dies Ergebnis war sehr veränderlich. Durchschnittswerte von Patienten waren: 300 mg/24 Std.

Es wurde festgestellt, daß die Darmaufnahme eine langsame war in Patienten mit osteoporotischer Krankheit.

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Author notes

  1. V. Parsons

    Present address: Department of Medicine, King's College Hospital Medical School, Denmark Hill, S.E.5, London

Authors and Affiliations

  1. Department of Medicine, Guy's Hospital Medical School, London

    V. Parsons,  N. Veall & W. J. H. Butterfield

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  1. V. Parsons
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  2. N. Veall
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  3. W. J. H. Butterfield
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Members of the External Scientific Staff of the Medical Research Council.

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Parsons, V., Veall, N. & Butterfield, W.J.H. The clinical use of orally administered47Ca for the investigation of intestinal calcium absorption. Calc. Tis Res. 2, 83–92 (1968). https://doi.org/10.1007/BF02279197

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