Abstract
Changes in the IgG concentration in the colostrum from separate teats of 6 sows and those in the sera of their 38 piglets were investigated. Colostrum was frequently sampled from parturition to 120 hours and blood was taken from the piglets from birth to 10 weeks of age. The IgG content of the colostrum decreased to 3.2% of the original concentration at the 5th day of lactation. The meaningful variation of the IgG concentration of the colostra obtained from different teats increased rapidly from 12 hours postpartum. Between-sow variation was high and no correlation of the IgG concentration of the colostrum with the average serum level of the corresponding litter could be confirmed. Of the newborn pigs, 33% possessed IgG before ingesting colostrum, the observed concentration was 0.09±0.02 mg/ml (mean±SEM). At 0.5 and 1.5 hours after access to colostrum, this value was 2.30±1.38 and 1.89±0.60 mg/ml respectively. The highest IgG concentration (39.45±1.46) was observed at 24 hours after birth. Following that, a stepwise drop occurred in the IgG level and the lowest value was observed in the 4th week of age (8.92±0.59 mg/ml). Subsequently, there was a continuous rise until 10 weeks of age when the concentration reached the value characteristic of adults. The calculated half-life of the IgG in the sera showed a significant between-litter variation. The average half-life of the serum IgG of pigs was 9.73 days.
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Allen, W.D. and Porter, P., 1973. The relative distribution of IgM and IgA cells in intestinal mucosa and lymphoid tissues of the young unweaned pig and their significance in ontogenesis of secretory immunity. Immunol., 24: 493–501.
Arsov, R., Rashkov, D., Vodas, K., Georgieva, D. and Bekyarova, N., 1977. Studies on the resorption of colostral globulins and the release of antibodies againstBacterium rhusiopathiae suis, Salmonella choleraesuis and beta-haemolyticEscherichia coli in newborn pigs. Vet. Sci. Sophia, 14: 26–32.
Berek, G., 1978. Comparative examination on rearing for piglets of low birth weight by freeze stored sow's and cow's colostrum. Állattenyésztés, 27: 263–271.
Bourne, F.J. and Curtis, J., 1973. Half-lives of immunoglobulins IgG, IgA and IgM in the serum of newborn pigs. Immunol., 24: 157–162.
Brandenburg, A.C. and Wilson, M.R., 1973. Immunity toEscherichia coli in pigs: IgG immunoglobulin in passive immunity toE. coli enteritis. Immunol., 24: 119–127.
Chaniago, T.D., Watson, D.L., Owen, R.A. and Johnson, R.H., 1978. Immunoglobulins in blood serum of foetal pigs. Aust. vet. J., 54: 30–33.
Curtis, J. and Bourne, F.J., 1971. Immunoglobulin quantitation in sow serum, colostrum and milk and the serum of young pigs. Biochim. Biophys. Acta, 236: 319–322.
Curtis, J. and Bourne, F.J., 1973. The transfer of immunoglobulins IgG, IgA and IgM from serum to colostrum and milk in the sow. Immunol., 24: 147–155.
Franek, M., Procházka, Z., Franz, J., Krejei, J. and Mensik, J., 1975. The transfer of131J-labelled immunoglobulins from serum to colostrum and milk in the sow. Acta vet. Brno, 44: 93–103.
Haye, S. and Kornegay, S.T., 1979. Immunoglobulin G, A and M antibody response in sow-reared and artificially-reared pigs. J. anim. Sci., 48: 1116–1122.
Jensen, P.T. and Pedersen, K.B., 1979. Studies on immunoglobulins and trypsin inhibitor in colostrum and milk from sows and in serum of their piglets. Acta vet. scand., 20: 60–72.
Jönsson, A., 1973. Transfer of immunoglobulins from mother to offspring in the pig. Acta vet. scand. Suppl., 43: 1–64.
Kim, Y.B., Bradley, S.G. and Watson, D.W., 1966a. Ontogeny of the immune response. I. Development of immunoglobulins in germ-free and conventional colostrumdeprived piglets. J. Immunol., 97: 52–63.
Kim, Y.B., Bradley, S.G. and Watson, D.W., 1966b. Ontogeny of the immune response. II. Characterisation of 19 S gammaG and 7 S gammaG immunoglobulins in the true primary and secondary responses in piglets. J. Immunol., 97: 189–195.
Lecce, J.G. and Matrone, G., 1960. Porcine neonatal nutrition: the effect of diet on the blood serum proteins and performance of the baby pig. J. Nutr., 70: 13–20.
Lecce, J.G. and Morgan, D.O., 1962. Effect of dietary regimen on cessation of intestinal absorption of large molecules (closure) in the neonatal pig and lamb. J. Nutr., 78: 263–268.
Lecce, J.G., Morgan, D.O. and Matrone, G., 1964. Effect of feeding colostral and milk component on the cessation of intestinal absorption of large molecules (closure) in neonatal pigs. J. Nutr., 84: 43–48.
Losonczy, S., Pethes, G., Frenyó, V.L., Antal, T. and Szabó, I., 1979. A quick physiological test to control optimal colostrum uptake by calves in largescale management. I. Pre- and post-colostral serum IgG concentration of calves. Magyar Állatorvosok Lapja, 34: 371–375.
Mancini, G., Carbonara, O. and Heremans, J.F., 1965. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochem., 2: 235–254.
Martinsson, K., 1970. Immunoglobulin therapy in piglets. Acta vet. scand. Suppl., 29: 1–56.
Metzger, J.J., Ballet-Lapierre, C. and Houdayer, M., 1978. Partial inhibition of the humoral immune response of pigs after early postnatal immunisation. Am. J. vet. Res., 39: 627–631.
Movsesijan, M., Hirstic, V., Bezbradica, L., Javovich, B., Pavlovich, A., Radojkovicz, Z., Tomic, V. and Nicolic, P., 1977. Absorption of immunoglobulin (IgG) in the newborn piglet. Vet. Glasnik, 12: 877–883.
Nordbring, F. and Olsson, B., 1958. Electrophoretic and immunological studies on the sera of young pigs. II. The effect of feeding bovine trypsin inhibitor with porcine colostrum on the absorption of antibodies and immune globulins. Acta Soc. Med. Upsal., 63: 25–40.
Pierce, A.E. and Smith, M.V., 1967. The in vitro transfer of bovine immune lactoglobulin across the intestine of newborn pigs. J. Physiol., 190: 19–34.
Porter, P., 1969. Porcine colostral IgA and IgM antibodies toEscherichia coli and their intestinal absorption by the neonatal piglet. Immunol., 17: 617–626.
Porter, P., 1973. Studies of porcine secretory IgA and its component chains in relation to intestinal absorption of colostral immunoglobulins by the neonatal pig. Immunol., 24: 173–176.
Porter, P. and Allen, W.D., 1972. Classes of immunoglobulins related to immunity in the pig. J. Am. vet. med. Assoc., 160: 511–520.
Porter, P. and Hill, I.R., 1970. Serological changes in immunoglobulins IgG, IgA and IgM andEscherichia coli antibodies in the young pig. Immunol., 18: 565–573.
Prokesova, L., Rejnek, J., Sterzl, J. and Travnicek, J., 1969. Isolation and characterisation of immunoglobulins in the serum of precolostral piglets. Fol. Microbiol., 14: 372–376.
Sasaki, M., Davis, C.L. and Larson, B.L., 1976. Immunoglobulin IgG1 metabolism in newborn calves. J. Dairy Sci., 60: 623–626.
Sterzl, J., Rejnek, J. and Travnicek, J., 1966. Impermeability of pig placenta for antibodies. Fol. Microbiol., 11: 7–11.
Watson, D.L., Bennel, M.A. and Chaniago, T.D., 1979. Effect of circulating maternally derived antibody on the development of local immune response in the intestine of the neonatal pig. Am. J. vet. Res., 40: 61–65.
Yabiki, T., Kashiwazaki, M. and Namioka, S., 1974. Quantitative analysis of three classes of immunoglobulins in serum of newborn pigs and milk of sows. Am. J. vet. Res., 35: 1483–1489.
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Frenyó, V.L., Pethes, G., Antal, T. et al. Changes in colostral and serum IgG content in swine in relation to time. Vet Res Commun 4, 275–282 (1980). https://doi.org/10.1007/BF02278503
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DOI: https://doi.org/10.1007/BF02278503