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The anemia of inflammatory disease in the dog I. The nature of the problem

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Abstract

The anemia of inflammatory disease (AID) in the dog is an almost invariable complication of infection, inflammation and disseminated or necrotizing neoplastic disease. Clinically innocuous, it is important only in the greater under-standing of the mechanisms controlling circulating erythrocyte quantity and quality. The etiology and pathogenesis include a shortened red cell life-span, disordered iron metabolism, depressed bone marrow response to the anemia and a disordered iron storage. The laboratory features of a moderate anemia, normal bone marrow cellular pattern, depression in iron metabolism and reticuloendothelial iron sequestration make a final diagnosis of AID dependent on ruling out other etiologic mechanisms which may obscure or aggravate the anemia of inflammatory disease in the dog.

Kurzfassung

Die Anämie der entzündlichen Erkrankung des Hundes ist eine komplizierende Begleiterscheinung von Infektionen, Entzündungen und disseminierten oder neoplastischen Erkrankungen. Klinisch unbedeutend ist diese Anämie nur im Sinne eines weiteren Verständnisses der Mechanismen bedeutsam, die Zahl und Menge der zirkulierenden Erythrozyten kontrollieren. Atiologie und Pathogenese umfassen eine verkürzte Lebensdauer der Erythrozyten, Störungen im Eisenstoffwechsel, unterdrückte Knochenmarksreaktion auf die Anämie und eine gestörte Eisenspeicherung. Laborwerte wie moderate Anämie, normale Knochenmarkszellbilder, unterdrückter Eisenstoffwechsel und RES-Eisen-Absonderung sprechen für die Diagnose einer Anämie der entzündlichen Erkrankung, vorausgesetzt, dass andere ätiologische Ursachen, die eine Anämie verschleiern oder erschweren können, ausgeschlossen werden.

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  1. Department of Clinical Pathology, School of Veterinary Medicine, University of California, 95616, Davis, California, (U.S.A.)

    B. F. Feldman & J. J. Kaneko

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  1. B. F. Feldman
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Feldman, B.F., Kaneko, J.J. The anemia of inflammatory disease in the dog I. The nature of the problem. Vet Res Commun 4, 237–252 (1980). https://doi.org/10.1007/BF02278500

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