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Corticosteroid-induced laminitis? Further observations on the isolated, perfused hoof

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Abstract

Isolated forefeet of healthy horses were pump-perfused with oxygenated Kreb's saline. Perfusion pressure increases were recorded following intra-arterial injection of histamine, serotonin and adrenaline. The same drugs were re-injected after the hoof vasculature had been perfused with hydrocortisone or betamethasone. The corticosteroids caused significant potentiation of the effects of adrenaline and serotonin, but not of histamine. It is suggested that the enhancement of the reactivity of the digital vasculature to neurohormones and mediators of inflammation may constitute a pharmacological basis for laminitis.

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References

  • Axelrod, J., 1963. The formation, metabolism uptake and release of noradrenaline and adrenaline. In: H. Varley and A.H. Gowenlock (Editors), Clinical Chemistry of Monoamines. Elsevier Publishing Co., Amsterdam, pp. 5–18.

    Google Scholar 

  • Besse, J.C. and Bass, A.D., 1966. Potentiation of hydrocortisone responses to catecholamines in vascular smooth muscle. J. Pharmacol. exp. Therap., 154: 224–238.

    Google Scholar 

  • Elmes, P.J. and Eyre, P., 1977. Vascular reactivity of the bovine foot to neurohormones, antigens and chemical mediators of anaphylaxis. Am. J. vet. Res., 38: 107–112.

    Google Scholar 

  • Eyre, P., Elmes, P.J. and Strickland, S., 1979. Corticosteroid-potentiated vascular responses of the equine digit: possible pharmacologic basic of laminitis. Am. J. vet. Res., 40: 135–138.

    Google Scholar 

  • Kalsner, S., 1969. Mechanism of hydrocortisone potentiation of responses to epinephrine and norepinephrine in rabbit aorta. Circ. Res., 24: 383–395.

    Google Scholar 

  • Muylle, E. and Oyaert, W., 1973. Lung function tests in obstructive pulmonary disease in horses. Equine vet. J., 5: 37–44.

    Google Scholar 

  • Robinson, N.E., Dabney, J.M. and Weidner, W.J., 1975. Vascular responses of the equine digit. Am. J. vet. Res., 36: 1248–1253.

    Google Scholar 

  • Vernimb, G.D., Van Hoose, L.M. and Hennessey, P.W., 1977. Onset and duration of corticosteroid effect after injection of betasone for treating equine arthropathics. Vet. Med. SAC., 72: 241–244.

    Google Scholar 

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Authors and Affiliations

  1. Pharmacology Laboratory, Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, (Canada)

    P. Eyre & P. J. Elmes

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  1. P. Eyre
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  2. P. J. Elmes
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Eyre, P., Elmes, P.J. Corticosteroid-induced laminitis? Further observations on the isolated, perfused hoof. Vet Res Commun 4, 139–143 (1980). https://doi.org/10.1007/BF02278492

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  • DOI: https://doi.org/10.1007/BF02278492

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