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Journal of Radioanalytical and Nuclear Chemistry

, Volume 134, Issue 2, pp 423–431 | Cite as

Preparation and evaluation of99mTc-thiodiglycolic acid (TDGA) for renal function studies

  • N. Ramamoorthy
  • S. A. Balakrishnan
  • S. M. Gaitonde
  • P. M. Pandey
  • U. N. Nayak
  • M. C. Patel
  • R. B. Patel
  • P. Ramanathan
Article

Abstract

Methods for the preparation and analysis of a new renal radiopharmaceutical,99mTc-thiodiglycolic acid (TDGA), are reported. The kit for Tc-TDGA contains a lypophilized acidic (pH 2.5) mixture of 5 mg TDGA and 0.05 mg SnCl2·2H2O. Acetate buffer has been found to be a suitable solvent for paper chromatography of99mTc-TDGA. The results of the quantitative organ distribution studies in rats and rabbits indicated the characteristics of99mTc-TDGA to be intermediate to the renal tubular agent131I-Hippuran and the GFR agent99mTc-DTPA.

Keywords

Acetate Chromatography Physical Chemistry 2H2O Inorganic Chemistry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Akadémiai Kiadó 1989

Authors and Affiliations

  • N. Ramamoorthy
    • 1
  • S. A. Balakrishnan
    • 1
  • S. M. Gaitonde
    • 1
  • P. M. Pandey
    • 1
  • U. N. Nayak
    • 2
  • M. C. Patel
    • 2
  • R. B. Patel
    • 2
  • P. Ramanathan
    • 2
  1. 1.Radiopharmaceuticals DivisionBhabha Atomic Research CentreBombay(India)
  2. 2.Radiation Medicine Centre, Bhabha Atomic Research CentreTMC Annex ParelBombay(India)

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