, Volume 35, Issue 5–6, pp 285–289 | Cite as

A study of the use of microdialysis probes as a sampling unit in on-line bioprocess monitoring in conjunction with column liquid chromatography

  • G. Marko-Varga
  • T. Buttler
  • L. Gorton
  • C. Grönsterwall


An automated on-line sampling and analytical set-up for the control of fermentations was studied incorporating a microdialysis probe as the sampling device. Applications to a penicillin broth and an ethanol fermentation were studied. Typical recovery values of carbohydrates were found to be close to 100% even after exposure of the microdialysis probe in the process for about 30 h.

Key Words

Column liquid chromatography Microdialysis Fermentation monitoring 


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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1993

Authors and Affiliations

  • G. Marko-Varga
    • 1
  • T. Buttler
    • 1
  • L. Gorton
    • 1
  • C. Grönsterwall
    • 2
  1. 1.Department of Analytical ChemistryUniversity of LundLundSweden
  2. 2.CMA/Microdialysis ABLundSweden

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