Skip to main content
Log in

Enantiomer separaton of tifluadom and analogues by liquid chromatography with cellulose-based chiral stationary phases

  • Originals
  • Published:
Chromatographia Aims and scope Submit manuscript

Summary

The resolution of nine recamic mixtures of tifluadom analogues has been evaluated using the chiral stationary phases Chiralcel OD and Chiralcel OJ. The separation was performed on an analytical scale to optimize the conditions for chiral resolution, approaching baseline separation, of the two enantiomers. Eight racemates were baseline separated on Chiralcel OJ using a mobile phase of hexane/2-propanol.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. R. L. Mueurisse, N. M. Blaton, O. M. Peeters, C. J. De Ranter, Acta Cryst. C48, 508 (1992); and references cited herein.

    Article  Google Scholar 

  2. R. L. Meurisse, J.-Cl. Menier, C. J. De Ranter, submitted to Eur. J. Pharmacol.

  3. D. Römer, H. H. Büscher, R. C. Hill, R. Maurer, P. I. Petcher, H. Zeugner, W. Benson, E. Finner, W. Milkowski, P. W. Thies, Life Sci.31, 1217 (1982).

    PubMed  Google Scholar 

  4. R. S. L. Chang, V. J. Lotti, T. B. Chem, M. E. Keegan, Neurosci. Lett.72, 211 (1986).

    Article  PubMed  Google Scholar 

  5. M. G. Block, R. M. DiPardo, B. E. Evans, K. E. Rittle, W. L. Whitter, D. F. Veber, R. M. Freidinger, R. S. L. Chang, T. B. Chen, V. J. Lotti, J. Med. Chem.33, 450 (1990).

    Article  PubMed  Google Scholar 

  6. T. J. Petcher, A. Widmer, U. Maetzel, H. Zeugner, Acta Cryst.C41, 909 (1985).

    Article  Google Scholar 

  7. E. J. Ariens, Eur. J. Clin. Pharmac.26, 663 (1984).

    Article  Google Scholar 

  8. S. G. Allenmark, Chromatographic Enantioseparation: Methods and Applications, Ellis Horwood Ltd., Chichester (1988).

    Google Scholar 

  9. Y. Okamoto, R. Aburatani, Y. Kaida, K. Hatada Chem. Lett., 1125 (1988).

  10. K.Ikeda, T. Hamasaki, H. Kohno, T. Ogawa, T. Matsumoto, J. Sakai, Chem. Lett., 1089 (1989).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Meurisse, R.L., De Ranter, C.J. Enantiomer separaton of tifluadom and analogues by liquid chromatography with cellulose-based chiral stationary phases. Chromatographia 38, 629–632 (1994). https://doi.org/10.1007/BF02277166

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02277166

Key Words

Navigation