Summary
Enantiomeric separation of amphetamine and methamphetamine as achiral derivatives on 2,6-di-O-pentyl-3-O-trifluoroacetyl-β-cyclodextrin, 2,6-di-O-pentyl-3-O-trifluoroacetyl-γ-cyclodextrin and 2,6-di-O-pentyl-3-O-propionyl-γ-cyclodextrin stationary phase in capillary gas chromatography is described. Trifluoroacetic anhydride and acetic anhydride were used as derivatizing reagents. Excellent precision was obtained for concentrations down to 0.1% / e.e. On 2,6-di-O-pentyl-3-O-propionyl-γ-cyclodextrin the elution order of R,S-amphetamine was reversed when the derivatizing reagent was changed but could not be reversed on any of the other phase types.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
J. Szejtli, Cyclodextrins and their Inclusion Complexes, Budapest, Akademic Kiado, 1982, pp. 261–264.
H. L. Jin, A. M. Stalcup, D. W. Armstrong, Chirality1, 137 (1989).
D. W. Armstrong, W. Demond, J. Chromatogr. Sci.22, 411 (1984).
D. W. Armstrong, X. Yang, S. M. Han, A. Menges, Anal. Chem.59, 2594 (1987).
A. M. Stalcup, H. L. Jin, D. W. Armstrong, J. Liquid Chromatogr.13, 473 (1990).
D. W. Armstrong, A. M. Stalcup, M. L. Hilton, J. D. Duncan, J. R. Faulkner, Jr., S. C. Chang, Anal. Chem.62, 1610 (1990).
D. W. Armstrong, M. Hilton, L. Coffin, LC-GC9, 646 (1991).
A. M. Stalcup, S. C. Chang, D. W. Armstrong, J. Chromatogr.513, 181 (1990).
E. Smolkova-Keulemansova, J. Chromatogr.251, 17 (1982).
E. Smolkova-Keulemansova, L. Feltl, S. Krysl, J. Chromatogr.241, 3 (1982).
E. Smolkova-Keulemansova, L. Feltl, S. Krysl, J. Inclusion Phenom.3, 183 (1985).
T. Koscleski, D. Syhilska, J. Jurczak, J. Chromatogr.280, 131 (1983).
V. Schurig, H.-P. Nowotny, J. Chromatogr.441, 155 (1988).
H.-P. Novotny, O. Schmalzing, V. Schurig, J. HRC.12, 383 (1989).
W. A. König, S. Lutz, G. Wenz, E. von der Bey, J. HRC.11, 506 (1988).
W. A. König, R. Krebber, P. Misschmck, J. HRC.12, 732 (1989).
D. W. Armstrong, W. Li, C. D. Chang, J. Pitha, Anal. Chem.62, 914 (1990).
D. W. Armstrong, W. Li, A. M. Stalcup, J. I. Seeman, H. V. Secor, Anal. Chem. Acta234, 365 (1990).
W. Li, H. L. Jin, D. W. Armstrong, J. Chromatogr.509, 303 (1990).
W. A. König, S. Lutz, G. Wenz, E. von der Bey, J. HRC.11, 506 (1988).
Z. Jin, H. L. Jin, Chromatographia38, 22 (1994).
L. R. Snyder, J. Chromatogr. Sci.10, 200 (1972).
D. W. Armstrong, W. DeMond, B. P. Czech, Anal. Chem.57, 481 (1985).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jin, H.L., Beesley, T.E. Enantiomeric separation of amphetamine and methamphetamine by capillary gas chromatography. Chromatographia 38, 595–598 (1994). https://doi.org/10.1007/BF02277160
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02277160