Irradiation modalities for photodynamic therapy
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For photodynamic therapy of tumors in hollow organs a homogeneous distribution of the applied laser light is desirable but often difficult to be achieved. Different irradiation modalities are compared in this paper. A method for homogenization of light using a layer of a highly backscattering medium deposited on the wall of the organ is described. The homogenization effect is studied theoretically for spherical and cylindrical hollow organs and, in part, compared with experimental results. An irradiation efficiency of more than 90% of the applied light dose is expected, i.e. losses can be reduced to 10% only.
KeywordsPhotodynamic Therapy Irradiation Modality Light Distribution Organ Wall Hollow Organ
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