Lasers in Medical Science

, Volume 4, Supplement 1, pp 159–164 | Cite as

Irradiation modalities for photodynamic therapy

  • E. Unsöld
  • W. Beyer
  • A. Heinze
  • R. Sroka
Session 2: Laser Systems and Delivery Systems

Abstract

For photodynamic therapy of tumors in hollow organs a homogeneous distribution of the applied laser light is desirable but often difficult to be achieved. Different irradiation modalities are compared in this paper. A method for homogenization of light using a layer of a highly backscattering medium deposited on the wall of the organ is described. The homogenization effect is studied theoretically for spherical and cylindrical hollow organs and, in part, compared with experimental results. An irradiation efficiency of more than 90% of the applied light dose is expected, i.e. losses can be reduced to 10% only.

Keywords

Photodynamic Therapy Irradiation Modality Light Distribution Organ Wall Hollow Organ 

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References

  1. (1).
    Jocham, D., Staehler, G., Chaussy, Ch., Unsöld, E., Hammer, C., Löhrs, and Löhrs U., Gorisch, W. Porphyrin Localisation and Treatment of Tumors (Doiron, D.R., Gomer, C.J., eds.), pp.249–256. Alan R. Liss, Inc., New York, 1984.Google Scholar
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    Star, M.W., Marijnissen, H.P.A., Jansen, H., Keijzer, M., and van Gemert, M.J.C. Photochem. Photobiol. 46:619–624.Google Scholar
  3. (3).
    Ulbricht, R. Elektrotechnische Zeitschrift 29:595–597.Google Scholar

Copyright information

© Bailliére Tindall 1989

Authors and Affiliations

  • E. Unsöld
    • 1
  • W. Beyer
    • 1
    • 2
  • A. Heinze
    • 1
    • 3
  • R. Sroka
    • 1
    • 4
  1. 1.GSF - Zentrales LaserlaboratoriumNeuherberg/MünchenF.R.G.
  2. 2.Urologische Klinik und PoliklinikUniversität MünchenMünchen 70F.R.G.
  3. 3.Klinik und Poliklinik für Kinder- und NeugeborenenchirurgieUniversität MünsterMünsterF.R.G.
  4. 4.Medizinische Klinik mit PoliklinikUniversität Erlangen-NürnbergErlangenF.R.G.

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