Summary
The glycosylation patterns of multiglycosylated proteins reflect both the cellular control of glycosyl transferase activity and the local control of the transfer event. Little information is available concerning these mechanisms. Changes in glycosylation occur in the disease state and provide a convenient way of examining the control mechanism(s) operating at individual glycosylation sites. Chromatographic methods have been applied to the human orosomucoid (OMD) isolated from seventeen different pathologies. Based on the distribution of the glycans at the individual sites it is clear that the major protein-glycan interactions that restrict glycosylation in “normal” OMD remain intact in the disease state in the presence of changing glycosyl transferase activity.
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Treuheit, M.J., Halsall, H.B. Restricted variation in the glycosylation of human α1-acid glycoprotein. Chromatographia 37, 144–148 (1993). https://doi.org/10.1007/BF02275851
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DOI: https://doi.org/10.1007/BF02275851