Summary
A high-performance liquid chromatographic method for the resolution of the enantiomers of a series ofN-alkyl-N-methylanilineN-oxides is reported. The resolutions were achieved using a Chiralcel, OD chiral stationary-phase with a mobile-phase of hexane and ethanol in varying proportions. The chromatographic order of elution of the enantiomers ofN-ethyl-N-methylanilineN-oxide was determined to be (+)-(R) before (−)-(S).
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Hadley, M.R., Damani, L.A., Hutt, A.J. et al. Enantiomeric resolution ofN-alkyl-N-methylanilineN-oxides by high-performance liquid chromatography. Chromatographia 37, 487–491 (1993). https://doi.org/10.1007/BF02275784
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DOI: https://doi.org/10.1007/BF02275784