, Volume 38, Issue 1–2, pp 62–70 | Cite as

Linearization of column responses by correlation chromatography. Separation improvement and reduction of undesired adsorption effects

  • D. J. Louwerse
  • H. C. Smit


Experiments and simulations prove that correlation chromatography can greatly reduce the disadvantage of a non-linear response of the chromatographic column. A factor that has been accepted as being an important source of error in correlation or multiplex chromatography, has been shown not to be. Separations affected, improve dramatically when correlation chromatography is used, and a substantial amount of correlation noise only arises when there is a large difference in separation between a conventional chromatogram and a correlogram.

A model has been developed for simulating these nonlinearities. It is shown that, especially for correlation chromatography, the simulation results match the practical measurements very well.

Key Words

Gas chromatography Correlation chromatography Simulation model Adsorption effects Separation improvement 


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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1994

Authors and Affiliations

  • D. J. Louwerse
    • 1
  • H. C. Smit
    • 1
  1. 1.Laboratory for Analytical ChemistryUniversity of AmsterdamAmsterdamThe Netherlands

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