Clinical Rheumatology

, Volume 1, Issue 2, pp 128–130 | Cite as

Ibuprofen-induced meningitis in mixed connective tissue disease

  • M. Hoffman
  • R. G. Gray
Case Report


A young Black woman with mixed connective tissue disease (MCTD) developed an aseptic meningitis after receiving ibuprofen. The meningeal reaction, reported infrequently in systemic lupus erythematosus (SLE) and only once previously in MCTD, was characterized by a predominantly polymorphonu-clear cerebrospinal fluid (CSF) pleocytosis and depression of CSF glucose. Reversible renal insuffiency also occurred. Features suggestive of a hypersensitivity reaction included pruritus, conjunctivitis, facial oedema, desquamation of the palms and soles, and subsequent near total alopecia. Meningeal signs responded rapidly to systemic corticosteroid therapy. Patients with MCTD as well as those with SLE may be at peculiar risk of developing this uncommon reaction to ibuprofen.

Key words

Ibuprofen Mixed connective tissue disease Meningitis Systemic lupus erythematosus 


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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • M. Hoffman
    • 1
  • R. G. Gray
    • 1
  1. 1.Department of MedicineTufts University School of Medicine at Baystate Medical Center SpringfieldUSA

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