Abstract
By means of a systematic spectroscopic study of an in vitro blood clot model, iron compounds involved in blood denaturation have been identified and evaluated at each stage of blood denaturation. So, a blood denaturation pattern is available for normal blood, but also for some pathological bloods (polyglobulic, Β-thalassemic and drepanocytic). Normal blood denaturation stands for a reference that will be used for several purposes. Thus, this study compares normal and pathological blood denaturation rates. Polyglobulic and Β-thalassemic blood denaturations are quite similar to normal blood denaturation. On the opposite, drepanocytic blood denaturation is really different (some hemochromes are not observed) and is a lot slower. This delay can be attributed to deoxyhemoglobin S fiber formation that could protect trapped compounds from oxidization.
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Jumpertz, C.M., Rimbert, J.N. In vitro spectroscopic study of normal and pathological blood denaturation. Hyperfine Interact 99, 353–366 (1996). https://doi.org/10.1007/BF02274940
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DOI: https://doi.org/10.1007/BF02274940