Rheumatology International

, Volume 10, Issue 4, pp 149–152 | Cite as

Lymphocyte infiltration and the synthesis of IgM and IgA rheumatoid factors by rheumatoid synovial membrane

  • M. Soden
  • A. Whelan
  • C. Feighery
  • B. Bresnihan


IgM and IgA rheumatoid factor (RF) synthesis by synovial membrane mononuclear cells was measured in 14 patients with rheumatoid arthritis (RA). The results were compared with blood mononuclear cell cultures and correlated with the intensity of lymphocyte infiltration of the synovium. IgM RF was produced by all synovial cultures compared with 56% of blood cultures; IgA RF was produced by 86% of synovial cultures and by 21% of blood cultures. A correlation was observed between synovial IgM RF synthesis, but not IgA RF synthesis, and the intensity of T cell and B cell infiltration of the synovial membrane.

Key words

Rheumatoid arthritis Synovial membrane Immunohistology Rheumatoid factor 


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • M. Soden
    • 1
  • A. Whelan
    • 2
  • C. Feighery
    • 2
  • B. Bresnihan
    • 1
  1. 1.University College Dublin, Department of RheumatologySt. Vincent's HospitalDublinIreland
  2. 2.University of Dublin, Department of ImmunologySt. James's HospitalDublinIreland

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