Skip to main content
SpringerLink
Log in

Experimental immune mediated arthritis in rhesus monkeys

A model for human rheumatoid arthritis?

  • Published:
Rheumatology International Aims and scope Submit manuscript

Summary

The induction of experimental arthritis in rhesus monkeys was studied by intradermal immunization of bovine type II collagen and antigens derived fromMycobacterium tuberculosis, Streptococcus pyogenes, andEubacterium aerofaciens. The tested bacterial antigens proved to be not arthritogenic. Bovine type II collagen induced clinical arthritis in 50% of the rhesus monkeys. Type II collagen induced arthritis in rhesus monkeys proved to be a potential model to study clinical, serological, histological, genetic, and immunologic features associated with human RA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Kelley WN, Harris ED, Ruddy S, Sledge CB (1985) Textbook of rheumatology, 2nd edn. Sanders, Philadelphia, Pa

    Google Scholar 

  2. Pearson CM (1964) Experimental models in rheumatoid disease. Arthritis Rheum 7: 80–86

    PubMed  Google Scholar 

  3. Holoshitz J, Drucker I, Yaretzky A, Eden W van, Klajman A, Lapidot Z, Frenkel A, Cohen IR (1986) T lymphocytes of rheumatoid arthritis patients show augmented reactivity to a fraction of mycobacteria cross-reactive with cartilage. Lancet II: 305–309

    Article  Google Scholar 

  4. Torisu M, Miyahara T, Shinohara N, Ohsato K, Sonozaki H (1978) A new side effect of BCG immunotherapy — BCG-induced arthritis in man. Cancer Immunol Immunother 5: 77–83

    Article  Google Scholar 

  5. Cromartie WJ, Craddock JG, Schwab JH, Anderle SK, Yang C-H (1977) Arthritis in rats after systemic injection of streptococcal cells or cell walls. J Exp Med 146: 1585–1602

    Article  PubMed  Google Scholar 

  6. Severijnen AJ, Kleef R van, Hazenberg MP, Merwe JP van de (1989) Cell wall fragments from major residents of the human intestinal flora induce chronic arthritis in rats. J Rheumatol 16: 1061–1068

    PubMed  Google Scholar 

  7. Cantazarro FJ, Stenson CA, Morris AJ, Chamowitz R, Rammelkamp CH, Stolzer BL, Perry WD (1954) Role of the streptococcus in the pathogenesis of rheumatic fever. Am J Med 17: 749–756

    Article  PubMed  Google Scholar 

  8. Greenstein AJ, Janowitz HD, Sachar DB (1976) The extra-intestinal complications of Crohn's disease and ulcerative colitis. A study of 700 patients. Medicine 55: 401–412

    PubMed  Google Scholar 

  9. Foidart J-M, Shigeto A, Martin GR, Zizic TM, Barnett EV, Lawley TJ, Katz SI (1978) Antibodies to type II collagen in relapsing polychondritis. N Engl J Med 299: 1203–1207

    PubMed  Google Scholar 

  10. Charriere G, Hartmann DJ, Vignon E, Ronziere M-C, Herbage D, Ville G (1988) Antibodies to types I, II, IX and XI collagen in the serum of patients with rheumatic diseases. Arthritis Rheum 31: 3, 325–331

    Google Scholar 

  11. Pereira RS, Black CM, Duance VC, Jones VE, Jacoby RK, Welsh KI (1985) Disappearing collagen antibodies in rheumatoid arthritis. Lancet II: 501–502

    Article  Google Scholar 

  12. Trentham DE (1982) Collagen arthritis as a relevant model for rheumatoid arthritis. Arthritis Rheum 25: 8, 911–916

    Google Scholar 

  13. Balner H (1977) The major histocompatibility system of subhuman primate species. In: Götze D (ed) The major histocompatibility system in man and animals. Springer, Berlin Heidelberg New York

    Google Scholar 

  14. Brown TMcP, Clark HW, Bailey JS, Gray CW (1971) A mechanistic approach to treatment of rheumatoid type arthritis naturally occurring in a gorilla. Trans Am Clin Climatol Assoc 82: 227–247

    Google Scholar 

  15. Benditt EP, Eriksen N (1972) Chemical characteristics of the substance of typical amyloidosis in monkeys. Acta Pathol Microbiol Scand [A] 80 [Suppl 233]: 103–108

    Google Scholar 

  16. Chapman WL, Crowell WA (1977) Amyloidosis in rhesus monkeys with rheumatoid arthritis and enterocolitis. JAVMA 171: 855–858

    PubMed  Google Scholar 

  17. Bywaters EGL (1981) Observations on chronic polyarthritis in monkeys. J R Soc Med 74: 794–799

    PubMed  Google Scholar 

  18. Rubin AS, Healy CT, Martin LN, Baskin GB, Roberts ED (1987) Experimental arthropathy induced in rhesus monkeys (Macaca mulatta) by intradermal immunization with native bovine type II collagen. Lab Invest 57 (5): 524–534

    PubMed  Google Scholar 

  19. Yoo TJ, Kim S-Y, Stuart JM, Floyd RA, Olson GA, Cremer MA, Kang AH (1988) Induction of arthritis in monkeys by immunization with type II collagen. J Exp Med 168: 777–782

    Article  PubMed  Google Scholar 

  20. Cathcart ES, Hayes KC, Gonnerman WA, Lazzari AA, Franzblau C (1986) Experimental arthritis in a nonhuman primate. Lab Invest 54: 26–31

    PubMed  Google Scholar 

  21. Zubler RH, Lange G, Lambert PH et al (1976) Detection of immune complexes in untreated sera by a modified125I-C1q binding test. J Immunol 116: 232–235

    PubMed  Google Scholar 

  22. Morgan K, Evans HB, Firth SA, Smith MN, Ayad S, Weiss JB, Holt PJL (1983) 1-alpha-2-alpha-3-alpha collagen is arthritogenic. Ann Rheum Dis 42: 680–683

    PubMed  Google Scholar 

  23. Griffiths MM, Eichwald EJ, Martin JH et al (1981) Immunogenetic control of experimental type II collagen-induced arthritis. I. Susceptibility and resistance among inbred strains of rats. Arthritis Rheum 24: 781–789

    PubMed  Google Scholar 

  24. Watson WC, Townes AS (1978) Genetic susceptibility to murine collagen II autoimmune arthritis. J Exp Med 162: 1878–1891

    Article  Google Scholar 

  25. Holmdahl R, Jansson L, Andersson M, Larsson E (1988) Immunogenetics of type II collagen autoimmunity and susceptibility to collagen arthritis. Immunology 65: 305–310

    PubMed  Google Scholar 

  26. Strom H, Möller E (1981) HLA and rheumatoid arthritis. Arthritis study of five families. Tissue Antigens 18: 92–100

    PubMed  Google Scholar 

  27. Khan MA, Kusher I, Braun WE et al (1981) Clinical and HLA studies in multiple case studies with rheumatoid arthritis. Tissue Antigens 18: 136–138

    PubMed  Google Scholar 

  28. Renick D, Niwayama G (1988) Diagnosis of bone and joint disorders, 2nd edn. Saunders, Philadelphia, Pa

    Google Scholar 

  29. Short CL, Bauer W, Reynolds WE (1957) Red-cell, white-cell, and differential counts. In: Short CL, Bauer W, Reynolds WE (eds) Rheumatoid arthritis. Harvard University Press, Cambridge, Mass, pp 349–356

    Google Scholar 

  30. Pepys MB (1981) C-reactive protein (CRP), serum amyloid P-component (SAP) and serum amyloid A protein (SAA) in autoimmune disease. In: Holborrow EJ (ed) Clinics and immunology and allergy, vol 1/1. Saunders, Eastbourne

    Google Scholar 

  31. Rodnan GP, Schumacher HR (1983) Primer on the rheumatic diseases. Arthritis Foundation, Atlanta, Ga

    Google Scholar 

  32. Toumbis A et al. (1963) Clinical and serological observations in patients with juvenile rheumatoid arthritis and their relatives. J Pediatr 62: 463–473

    PubMed  Google Scholar 

  33. Selroos O (1972) Thrombocytosis in rheumatoid arthritis. Scand J Rheumatol 1: 136–140

    Google Scholar 

  34. Jasin HE (1985) Autoimmunity specificities of immune complexes requested in articular cartilage of patients with rheumatoid arthritis and osteoarthritis. Arthritis Rheum 28: 241–248

    PubMed  Google Scholar 

  35. Morrow J, Isenberg D (1987) Autoimmune rheumatic disease. Blackwell, Oxford

    Google Scholar 

  36. Mottonen T, Hannonen P, Oka M, Rautiainen J, Jokinen I, Arvilommi H, Palosuo T, Aho K (1988) Antibodies against native type II collagen do not precede the clincial onset of rheumatoid arthritis. Arthritis Rheum 31: 776–779

    PubMed  Google Scholar 

  37. Pereira R, Black CM, Duance VC, Jones VE, Jacoby RK, Welsh KI (1985) Disappearing collagen antibodies in rheumatoid arthritis. Lancet II: 501–502

    Article  Google Scholar 

  38. Holmdahl R, Klareskog L, Rubin K, Larsson E, Wigzell H (1985) T lymphocytes in collagen II-induced arthritis in mice. Scand J Immunol 22: 295–306

    PubMed  Google Scholar 

  39. Brahn E, Trentham DE (1984) Effect of antithymocyte serum on collagen arthritis in rats: evidence that T cells are involved in its pathogenesis. Cell Immunol 86: 421–428

    Article  PubMed  Google Scholar 

  40. Londei M, Savill CM, Verhoef A, Brennan F, Leech ZA, Duance V, Maini RN, Feldmann M (1989) Persistence of collagen type II-specific T-cell clones in the synovial membrane of a patient with rheumatoid arthritis. Proc Natl Acad Sci USA 86: 636–640

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. TNO Primate Center, Lange Kleiweg 151, P.O. Box 5815, NL-2280, Rijswijk, HV, The Netherlands

    N. P. M. Bakker, M. G. van Erck, R. E. Bontrop & M. Jonker

  2. TNO-IVEG Institute, NL-2280, Rijswijk, HV, The Netherlands

    C. Zurcher

  3. Department of Rheumatology, Sint Radboud Hospital, University of Nijmegen, NL-6525, Nijmegen, GA, The Netherlands

    P. Faaber

  4. Department of Radiologic Diagnosis, Sint Radboud Hospital, University of Nijmegen, NL-6525, Nijmegen, GA, The Netherlands

    A. Lemmens

  5. Department of Immunology, Erasmus University, NL-3000, Rotterdam, DR, The Netherlands

    M. Hazenberg

Authors
  1. N. P. M. Bakker
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. G. van Erck
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. Zurcher
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. Faaber
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. Lemmens
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. Hazenberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. R. E. Bontrop
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. M. Jonker
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bakker, N.P.M., van Erck, M.G., Zurcher, C. et al. Experimental immune mediated arthritis in rhesus monkeys. Rheumatol Int 10, 21–29 (1990). https://doi.org/10.1007/BF02274777

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02274777

Key words

Search

Navigation