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Chromatographia

, Volume 31, Issue 3–4, pp 143–146 | Cite as

Prediction of retention of O-ethyl, O-aryl and N-isopropyl phosphoroamidothioates in RP-HPLC from molecular structure parameters

  • H. F. Zou
  • Q. S. Wang
  • R. Y. Gao
  • H. Z. Yang
  • B. W. Yang
  • Y. K. Zhang
  • P. C. Lu
Originals

Summary

Multi-variable regression analysis between lnkw, c (in retention equation lnk′=lnkw+cCb) and molecular structure parameters, including hydrophobicity, electric effect, field effect and position-specific effect constant, was carried out with O-ethyl, O-aryl and N-isopropyl phosphoroamidothioates as test solutes. With these quantitative relationships, the retention behaviour of these solutes for different mobile phase compositions was predicted. The results showed that there are only 26.7% of total, experimentally measured, capacity factors with relative deviations larger than 5% and only 2.2% with deviations larger than 10%, which means that it is possible to apply the method reported to predict retention values for qualitative purposes for different mobile phase compositions.

Key Words

Column liquid chromatography Molecular structure parameters Prediction of retention Phosphoroamidothiotes 

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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1991

Authors and Affiliations

  • H. F. Zou
    • 1
  • Q. S. Wang
    • 2
  • R. Y. Gao
    • 2
  • H. Z. Yang
    • 2
  • B. W. Yang
    • 2
  • Y. K. Zhang
    • 1
  • P. C. Lu
    • 1
  1. 1.Dalian Chromatographic R&D Center of China, Dalian Institute of Chemical PhysicsAcademia SinicaDalianP.R. China
  2. 2.Institute of Elemento-Organic ChemistryNankai UniversityTanjingP.R. China

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