Aesthetic Plastic Surgery

, Volume 15, Issue 1, pp 327–337 | Cite as

Dimethylsulfoxide (DMSO) for human single-stage intraoperative tissue expansion and circulatory enhancement

  • Charles A. Vinnik
  • Stanley W. Jacob
Article

Abstract

Dimethylsulfoxide (DMSO) has been in clinical use since the early 1960s. In 1967 the discovery that DMSO can greatly reduce ischemia in experimental pedicle flaps stimulated its use in plastic surgery by the authors since 1976. In 1987 its ability to soften collagen, thus permitting degrees of immediate intraoperative tissue expansion hitherto unknown, was applied clinically for the first time. Evolving use of topical 70% DMSO alone, in combination with intravenous DMSO, and intravenous DMSO alone with greater efficacy is discussed. Cases of intraoperative tissue expansion for large lesion excision and use in abdominoplasty to maximize skin resection are discussed. In breast reconstruction, maximal tissue expansion in minutes with immediate placement of large permanent prostheses ends the delay of reconstruction and problems of chronic tissue expander capsule formation and gives this technique a clear advantage over other reconstructive techniques.

Key words

Preliminary report DMSO Tissue expansion Abdominoplasty Breast reconstruction Suction lipoplasty Toxicity studies Controversies 

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References

  1. 1.
    Adamson JE, Horton CE, Crawford HH, Ayer S: Studies on action of dimethyl sulfoxide on experimental pedicle flap. Plast Reconstr Surg39:142, 1967Google Scholar
  2. 2.
    Baker J: Classification of spherical breast contractures. Read at Aesthetic Breast Symposium, Scottsdale, AZ, USA 1975Google Scholar
  3. 3.
    Erk Y, Raskin DJ, Mace M Jr: In: de La Torre JC (ed). Dimethyl sulfoxide alteration of collagen. NY Acad Sci411:364–368, 1983Google Scholar
  4. 4.
    Gries F, Bublitz G, Lindner J: The effect of dimethyl sulfoxide on the components of connective tissue. Ann NY Acad Sci141:630–637, 1967Google Scholar
  5. 5.
    Jacob S, Rosenbaum E, Wood D: DMSO: Basic Concepts, New York, Marcel Dekker, 1971, vol 4, pp 133–143Google Scholar
  6. 6.
    Liang MD, Dick GO, Narayanan K: Topical DMSO: enhancement of tissue expansion. Plast Surg Forum at 56th Annual ASPRS Meeting10:205–207, 1987Google Scholar
  7. 7.
    Muther, RS, Bennett WM: Effects of dimethylsulfoxide on renal function in man.244:2081–2083 1980.Google Scholar
  8. 8.
    Rubin LF, Barnett KC: Ocular effects of oral and dermal applications of dimethyl sulfoxide in animals. Ann NY Acad Sci141:345, 1967Google Scholar
  9. 9.
    Sasaki G: Protocol using 70% topical DMSO over 3 days preop, personal communication, August 12, 1988Google Scholar
  10. 10.
    Vinnik CA: An intravenous dissociation technique for outpatient plastic surgery. Plast Reconstr Surg67:799–805, 1978Google Scholar
  11. 11.
    Vinnik CA: Silicone mastopathy. Owsley J, Peterson R (eds). Symposium on Aesthetic Surgery of the Breast. St. Louis: C.V. Mosby Co, 1978, vol 21, pp 151–156Google Scholar
  12. 12.
    Vogin EE, Carsons-Cannon CR, Linegar CR, Rubin LF: Chronic toxicity of DMSO in primates. Toxicol Appl Pharmacol16:606–612, 1970Google Scholar
  13. 13.
    Waller FT, Tanabe CT, Paxton HD: Treatment of elevated intracranial pressure with dimethylsulfoxide. Ann NY Acad Sci411:286–293, 1983Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1991

Authors and Affiliations

  • Charles A. Vinnik
    • 2
    • 1
  • Stanley W. Jacob
    • 2
    • 1
  1. 1.Department of Surgery at Oregon Health Sciences UniversityPortlandUSA
  2. 2.Las VegasUSA

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