Diffusion of drugs through multibarrier
- 25 Downloads
Diffusional mass transfer across a serial 2 or 3 unit laminate barrier of ethyl cellulose and polyethylene glycol membranes was studied using caffeine and salicylic acid as model drugs. The overall membrane diffusional resistance was found to be the sum of the intrinsic membrane resistances. When the resistance of one layer was much higher than that of the others, the permeability was then controlled by the single layer in the laminate.
KeywordsPublic Health Cellulose Ethyl Internal Medicine Mass Transfer
Unable to display preview. Download preview PDF.
- Ballard, B. E., and E.Nelson (1965) In:Remington's Pharmaceutical Sciences, 13th ed., 612–640.Google Scholar
- Crank, J. (1957)The mathematics of diffusion. Oxford Univ. Press, 42–55.Google Scholar
- Donbrow, M., andM. Friedman (1974).J. Pharm. Pharmacol. 26, 148–150;Ibidem (1975a)27, 633–646;Ibidem 0975b).J. Pharm. Sci. 64, 76–80.Google Scholar
- Friedman, M., andM. Donbrow (1978)Drug Dev. Ind. Pharmacy 4, 319–333;Ibidem (1979)J. Pharm. Pharmacol. 31, 396–399.Google Scholar
- Jost, W. (1960)Diffusion in solids, liquids, gases. Academic Press, New York, 8–12.Google Scholar
- Scheuplein, R. J. (1968)J. Theoret. Biol. 18, 72–89.Google Scholar
- Zwolinski, B. Y., H. Evring andC. E. Reese (1949)J. Physiol. Colloid Chem. 53, 1426–1453.Google Scholar