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The analytical consequence of the decomposition of prednisolone to 17-deoxyprednisolone in stability control

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Abstract

17-Deoxyprednisolone, a decomposition product of prednisolone, interferes in some stability-indicating spectrophotometric methods for corticosteroids. The false positive reaction of 17-deoxyprednisolone with tetrazolium blue and with the method ofBundgaard andHansen (1979), is discussed.

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Authors and Affiliations

  1. Department of Analytical Pharmacy, Faculty of Pharmacy, State University of Utrecht, Catharijnesingel 60, 3511, GH Utrecht, The Netherlands

    D. Dekker

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  1. D. Dekker
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Dekker, D. The analytical consequence of the decomposition of prednisolone to 17-deoxyprednisolone in stability control. Pharmaceutisch Weekblad Scientific Edition 2, 280–281 (1980). https://doi.org/10.1007/BF02272994

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  • DOI: https://doi.org/10.1007/BF02272994

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