Summary
Different ways used for enhancing the yield of sulphonamides leached from solid supports are reported. Supercritical CO2 and methanol-modified CO2 were used as extractants of the target analytes and the impregnation of the solid sample with buffer, derivatization of the analytes and ion-pair formation were assessed. Only the sulphonamide/tetramethyl-ammonium ion-pairs are quantitatively extracted from the solid supports using pure supercritical CO2, while the other modifications and the presence of a cosolvent lead to recoveries lower than 30% for most of the analytes. Individual separation/quantitation of the analytes was performed off-line using a liquid chromatograph.
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Tena, M.T., Luque de Castro, M.D. & Valcárcel, M. Improved supercritical fluid extraction of sulphonamides. Chromatographia 40, 197–203 (1995). https://doi.org/10.1007/BF02272171
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DOI: https://doi.org/10.1007/BF02272171