Determination of fosfomycin in human urine by capillary gas chromatography: Application to clinical pharmacokinetic studies
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A capillary gas chromatographic method for the determination of fosfomycin in human urine is described. After dilution of the sample and derivatization, analysis was on a HP-1 capillary column and a flame ionization detector was used to determine the bistrimethylsilyl derivative of fosfomycin. Response was linear in the range 50–5000 μg mL−1. The detection limit was about 10 μg mL−1. The within and between day coefficients of variation did not exceed 6%. The method was applied to the determination of fosfomycin in urine samples collected during clinical pharmacokinetic studies.
Key WordsGas chromatography Fosfomycin in urine Pharmacokinetics
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