Chromatographia

, Volume 43, Issue 5–6, pp 293–295 | Cite as

Determination of fosfomycin in human urine by capillary gas chromatography: Application to clinical pharmacokinetic studies

  • M. C. Dios-Viéitez
  • M. M. Goñi
  • M. J. Renedo
  • D. Fos
Originals

Summary

A capillary gas chromatographic method for the determination of fosfomycin in human urine is described. After dilution of the sample and derivatization, analysis was on a HP-1 capillary column and a flame ionization detector was used to determine the bistrimethylsilyl derivative of fosfomycin. Response was linear in the range 50–5000 μg mL−1. The detection limit was about 10 μg mL−1. The within and between day coefficients of variation did not exceed 6%. The method was applied to the determination of fosfomycin in urine samples collected during clinical pharmacokinetic studies.

Key Words

Gas chromatography Fosfomycin in urine Pharmacokinetics 

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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1996

Authors and Affiliations

  • M. C. Dios-Viéitez
    • 1
  • M. M. Goñi
    • 1
  • M. J. Renedo
    • 1
  • D. Fos
    • 1
  1. 1.Departamento de Farmacia y Tecnología Farmacéutica, Facultad de FarmaciaUniversidad de NavarraPamplonaSpain

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