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Chromatographia

, Volume 9, Issue 9, pp 425–432 | Cite as

Occurrence and prevention of isomerization of some monoterpene hydrocarbons from essential oils during liquid-solid chromatography on silica gel

  • J. J. C. Scheffer
  • A. Koedam
  • A. Baerheim Svendsen
Originals

Summary

During LSC of naturally occurring monoterpene hydrocarbon mixtures from essential oils using silica gel as adsorbent alterations in the composition of the mixtures were observed by means of gas chromatography. Impurities (metals) and active sites on dried silica gels were found to be responsible for a series of isomerizations of a number of the constituents. After purification by washing the silica gel with acid and base and after deactivation of the dried silica gel by adding water (5%) the isomerization processes could be avoided. This was tested by means of the monoterpene hydrocarbon mixtures of three essential oils and a number of pure monoterpene hydrocarbons.

Keywords

Chromatography Analytical Chemistry Purification Organic Chemistry Hydrocarbon 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Friedr. Vieweg & Sohn Verlagschesellschaft mbH 1976

Authors and Affiliations

  • J. J. C. Scheffer
    • 1
  • A. Koedam
    • 1
  • A. Baerheim Svendsen
    • 1
  1. 1.Department of PharmacognosyState University of Leyden, Gorlaeus LaboratoriesLeydenThe Netherlands

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