, Volume 11, Issue 11, pp 640–644 | Cite as

Preparative liquid chromatography: History and trends

  • E. Geeraert
  • M. Verzele


Tswett was the first to develop preparative chromatography. The evolution of this technique is sketched: from column extrusion to current day elution; from small to coarse particles and back again to small ones. Recent trends are finally pointed out.


Chromatography Analytical Chemistry Organic Chemistry Liquid Chromatography Recent Trend 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. [1]
    L. Zechmeister andL. v. Cholnoky, Monatsh. Chem.68, 68–80 (1936).CrossRefGoogle Scholar
  2. [2]
    T. I. Williams, An Introduction to Chromatography, Blackie & Son Ltd., London and Glasgow, 1947.Google Scholar
  3. [3]
    R. Kuhn andE. Lederer, Ber. Deut. Chem. Ges.64, 1349–57 (1931).Google Scholar
  4. [4]
    R. Kuhn, A. Winterstein andE. Lederer, Hoppe-Seyler's Z. Physiol. Chem.197, 141–160 (1931).Google Scholar
  5. [5]
    R. Kuhn andH. Brockmann, Hoppe-Seyler's Z. Physiol. Chem.206, 41–64 (1932).Google Scholar
  6. [6]
    A. Winterstein andG. Stein, Hoppe-Seyler's Z. Physiol. Chem.220, 247–277 (1933).Google Scholar
  7. [7]
    A. Winterstein andK. Schön, Hoppe-Seyler's Z. Physiol. Chem.230, 139–145 (1934).Google Scholar
  8. [8]
    P. Karrer andK. Schöpp, Helv. Chim. Acta15, 745–746 (1932).CrossRefGoogle Scholar
  9. [9]
    P. Karrer andO. Walker, Helv. Chim. Acta16, 641–643 (1933).CrossRefGoogle Scholar
  10. [10]
    P. Karrer, O. Walker, K. Schöpp andR. Morf, Nature132, 26 (1933).Google Scholar
  11. [11]
    P. Karrer andK. Schöpp, Helv. Chim. Acta17, 693 (1934).CrossRefGoogle Scholar
  12. [12]
    P. Karrer andF. M. Strong. Helv. Chim. Acta19, 25–28 (1936).CrossRefGoogle Scholar
  13. [13]
    L. Zechmeister andL. v. Cholnoky, J. Liebigs Ann. Chem.509, 269–287 (1934).Google Scholar
  14. [14]
    H. H. Strain, J. Biol. Chem.105, 523–535 (1934).Google Scholar
  15. [15]
    L. Zechmeister andL. v. Cholnoky, Die chromatographische Adsorptionsmethode. Grundlagen—Methodik—Anwendungen, Wien, Verlag von J. Springer, 1937.Google Scholar
  16. [16]
    R. M. Scott, J. Chromatog. Sci.11, 129–135 (1973).Google Scholar
  17. [17]
    C. J. Williams andR. E. Hawley, Int Lab., Sept/Oct, 67–76 (1975).Google Scholar
  18. [18]
    J. J. Kirkland, Modern Practice of Liquid Chromatography, (ed.J. J. Kirkland) Wiley-Interscience, New York, 1971.Google Scholar
  19. [19]
    R. E. Majors, Anal. Chem.44, 1722–1726 (1972).CrossRefGoogle Scholar
  20. [20]
    L. R. Snyder andJ. J. Kirkland, Introduction to Modern Liquid Chromatography, Wiley- Interscience Publ., 1974.Google Scholar
  21. [21]
    Z. Deyl, K. Macek andJ. Janak, Liquid Column Chromatography. A Survey of Modern Techniques and Applications, Elsevier Scient. Publ. Co. 1975.Google Scholar
  22. [22]
    H. Veening, Critic. Rev. Anal. Chem.5, 165–200 (1975).Google Scholar
  23. [23]
    Chem. Eng. News46, Mar. 25, 62–63 (1968).Google Scholar
  24. [24]
    R. S. Timmins, L. Mir andJ. M. Ryan, Chem. Eng.,76, 170–178 (1969).Google Scholar
  25. [25]
    R. F. Baddour, U. S. 3.250.058 (1966).Google Scholar
  26. [26]
    J. Porath, Gas Chromatography, Copenhagen, 1968, (ed.Harbourn), pp. 201–216.Google Scholar
  27. [27]
    J. L. Mulder andF. A. Buytenhuys, J. Chromatogr.51, 459–477 (1970).CrossRefGoogle Scholar
  28. [28]
    K. Aizetmüller, J. Chromatogr.73, 248–252 (1972).CrossRefGoogle Scholar
  29. [29]
    E. V. Piel, Anal. Chem.38, 370–372 (1966).CrossRefGoogle Scholar
  30. [30]
    S. T. Sie andN. van den Hoed, J. Chromatog. Sci.7, 257–266 (1969).Google Scholar
  31. [31]
    J. J. DeStefano andH. C. Beachell, J. Chromatog. Sci.8, 434–438 (1970).Google Scholar
  32. [32]
    H. C. Beachell andJ. J. DeStefano, J. Chromatog., Sci.10, 481–486 (1972).Google Scholar
  33. [33]
    J. J. DeStefano andH. C. Beachell, J. Chromatog. Sci.10, 654–662 (1972).Google Scholar
  34. [34]
    J. P. Wolf, Anal. Chem.45, 1248–1250 (1973).CrossRefGoogle Scholar
  35. [35]
    J. P. Larman, R. C. Williams andD. R. Baker, Chromatographia8, 92–96(1975).Google Scholar
  36. [36]
    E. Godbille andP. Devaux, J. Chromatog. Sci.12, 564–569 (1974).Google Scholar
  37. [37]
    E. Godbille andP. Devaux, J. Chromatogr.122, 317–329 (1976).CrossRefGoogle Scholar
  38. [38]
    J. N. Little, R. L. Cotter, J. A. Prendergast andP. D. McDonald, J. Chromatogr.126, 439–445 (1976).CrossRefGoogle Scholar
  39. [39]
    M. Verzele, in Instrumentation in Gas Chromatography, (ed.J. Krugers), Centrex Publ. Co., Eindhoven, 1968, pp. 159–177.Google Scholar
  40. [40]
    J. Albrecht andM. Verzele, J. Chromatog. Sci.9, 745–749 (1971).Google Scholar
  41. [41]
    K. J. Bombaugh andP. W. Almquist, Chromatographia8, 109–118 (1975).Google Scholar
  42. [42]
    R. P.W. Scott andP. Kucera, J. Chromatogr.119, 467–482 (1976).CrossRefGoogle Scholar
  43. [43]
    J. H. Done, J. Chromatogr.125, 43–57 (1976).CrossRefGoogle Scholar
  44. [44]
    A. Wehrli, U. Hermann andJ. F. K. Huber, J. Chromatogr.125, 59–70 (1976).CrossRefGoogle Scholar
  45. [45]
    A. W. J. De Jong, H. Poppe andJ. C. Kraak, J. Chromatogr.148, 127–141 (1978).CrossRefGoogle Scholar
  46. [46]
    A. Wehrli, Z. Anal. Chem.277, 289–302 (1975).CrossRefGoogle Scholar
  47. [47]
    K. E. Conroe, Chromatographia8, 119–120 (1975).Google Scholar

Copyright information

© Friedr. Vieweg & Sohn Verlagschesellschaft mbH 1978

Authors and Affiliations

  • E. Geeraert
    • 1
  • M. Verzele
    • 1
  1. 1.Laboratory of Organic ChemistryState University of GhentGentBelgium

Personalised recommendations