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Structural effects and retention in reversed-phase ion-pair chromatography of 2-benzoylbenzoic acid derivatives

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Summary

The retention behaviour of twenty derivatives of 2-benzoylbenzoic acid was investigated in reversed-phase (RP) systems consisting of octadecyl silica (LiChrosorb RP-18) as the column packing material eluted with buffer-methanol mixtures containing low concentrations of cetyltrimethylammonium bromide (cetrimide).

Owing to the linear relationships between logk′ and % cetrimide or % methanol in the mobile phase, the effects of the individual substituents on retention were quantified by using the group contribution parameter Δ logk′. Correlation between HPLC and HPTLC data for the same RP systems was analysed.

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Authors and Affiliations

  1. Department of Inorganic and Analytical Chemistry, Pharmaceutical Faculty, Medical Academy, Lublin, Poland

    M. Bieganowska, E. Soczewiński & M. Janowska

Authors
  1. M. Bieganowska
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  2. E. Soczewiński
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  3. M. Janowska
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Bieganowska, M., Soczewiński, E. & Janowska, M. Structural effects and retention in reversed-phase ion-pair chromatography of 2-benzoylbenzoic acid derivatives. Chromatographia 18, 99–102 (1984). https://doi.org/10.1007/BF02268466

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  • DOI: https://doi.org/10.1007/BF02268466

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