Chromatographia

, Volume 26, Issue 1, pp 101–109 | Cite as

An expert system for the selection of criteria for selectivity optimization in high-pressure liquid chromatography

  • Anne Peeters
  • Lutgarde Buydens
  • Desire L. Massart
  • P. J. Schoenmakers
Article

Summary

Systematic procedures for the optimization of chromatographic selectivity require objective criteria to characterize the quality of separation in a chromatogram. Numerous criteria have been suggested. Different criteria yield different results and the choice will depend on a large number of factors. It is genuinely difficult to select the most suitable criterion in a particular situation. For these reasons, an expert system has been developed to assist chromatographers in the selection of optimization criteria. A structured representation of the required knowledge and its implementation in an expert-system shell are presented in this paper.

Key Words

Column liquid chromatography Expert systems Selectivity optimization Optimization criteria 

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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1988

Authors and Affiliations

  • Anne Peeters
    • 1
  • Lutgarde Buydens
    • 1
  • Desire L. Massart
    • 1
  • P. J. Schoenmakers
    • 2
  1. 1.Farmaceutisch InstituutVrije Universiteit BrusselBrusselsBelgium
  2. 2.Philips ResearchEindhovenThe Netherlands

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