Skip to main content
SpringerLink
Log in

Cold caloric microcirculatory reflex disturbance in patients with Parkinson's disease

  • Research Paper
  • Published:
Clinical Autonomic Research Aims and scope Submit manuscript

Abstract

The basal skin microcirculatory blood flow and its change in response to a cold caloric stimulus (cold water, 5°C, exposure of one foot for 30 s) were investigated in nine patients with Parkinson's disease (PD) and nine normal subjects (controls). The results revealed a significant (p<0.001) difference between the groups. In the controls there was a strong decrease in the red cell flux (RCF) on cold water exposure, while eight of the nine PD patients revealed no detectable change in RCF; in one patient only there was a less pronounced reaction. It was concluded that the regulation of the microcirculatory blood flow was affected in PD patients; the cold caloric reflec was attenuated or absent but there was no difference in the basal microcirculatory blood flow compared to normal subjects.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Micieli F, Tassorelli C, Martignoni Eet al. Disordered pupil reactivity in Parkinson's disease.Clin Autonom Res 1991;1:55–58.

    Article  Google Scholar 

  2. Goetz CG, Lutge W, Tanner CM. Autonomic dysfunction in Parkinson's disease.Neurology 1986;36: 73–75.

    PubMed  Google Scholar 

  3. Appenzeller O, Goss JE. Autonomic deficits in Parkinson's syndrome.Arch Neurol 1971;24: 50–57.

    PubMed  Google Scholar 

  4. Logemann JA, Blonsky ER, Boshes B. Dysphagia in parkinsonism.JAMA 1975;231 (1): 69–70.

    Article  Google Scholar 

  5. Tanner CM, Goetz CG, Hlawans HL. Autonomic nervous system disorders. In: Koller WC, ed.Handbook of Parkinson's Disease. New York: Marcel Dekker Inc., 1987; 145–170.

    Google Scholar 

  6. Janig W. Functions of the sympathetic innervation of the skin. In: Loewy AD, Spyer KM, eds.Central Regulation of Autonomic Functions. New York: Oxford University Press, 1990; 334–349.

    Google Scholar 

  7. Warwick-Evans LA, Church RE, Hancock C, Jochim D, Morris PH, Ward F. Electrodermal activity as an index of motion sickness.Aviat Space Environ Med 1987;58: 417–423.

    PubMed  Google Scholar 

  8. Johnson JM. The cutaneous circulation. In: Shepherd AP, Oberg PA, eds.Laser-Doppler Blood Flowmetry. Boston: Kluwer Academic Publishers, 1990; 21–139.

    Google Scholar 

  9. Jellinger K. Overview of morphological changes in Parkinson's disease. In: Yahr MD, Bergmann KJ, eds.Parkinson's Diseases. New York: Raven Press, 1986; 1–18.

    Google Scholar 

  10. Langston JW, Forno LS. The hypothalamus in Parkinson's disease.Ann Neurol 1978;3: 129–133.

    Article  PubMed  Google Scholar 

  11. Javoy-Agid F, Ruberg M, Pique Let al. Biochemistry of the hypothalamus in Parkinson's disease.Neurology 1984;34: 672–675.

    PubMed  Google Scholar 

  12. Agid Y, Ruberg M, Dubouis Bet al. Parkinson's disease and dementia.Clin Neuropharmacol 1986;9(suppl. 2): 522–536.

    Google Scholar 

  13. Agid Y, Ruberg M, Dubouis B, Javoy-Agid F. Biochemical substrates of mental disturbances in Parkinson's disease. In: Hassier RG, Christ JF, eds.Parkinson-specific Motor and Mental Disorders. New York: Raven Press, 1984; 211–218.

    Google Scholar 

  14. Pirozzolo FJ, Swihart AA, Rey G, Jankovic J, Mortimer JA. Cognitive impairments associated with Parkinson's disease and other movement disorders. In: Jankovic J, Tolosa E, eds.Parkinson's Disease and Movement Disorders. Baltimore: Urban & Schwarzenberg, 1988; 425–440.

    Google Scholar 

  15. Hubble JP, Venkatesh R, Hassanein RES, Gray C, Koller WC. Personality and depression in Parkinson's disease.J Nervous Mental Dis 1990;181(11):657–662.

    Google Scholar 

  16. Hermsmeyer K, Akbarali H. Cellular pacemaker mechanism in vascular muscle. In: Intaglietta M, ed.Vasomotion and Flow Modulation in the Microcirculation New York: Karger, 1989; 32–40.

    Google Scholar 

  17. Salerud EG, Tenland T, Nilsson GE, Oberg PA: Rhythmical variations in human skin blood flow.Int J Microcir: Clin Exp 1983;2: 91–102.

    Google Scholar 

Download references

Author information

Author notes

  1. O. I. Kolev MD PhD (Visiting Scientist)

    Present address: Division of Space Life Sciences, Universities Space Research Association, Houston, Texas, USA

Authors and Affiliations

  1. Linköping University Hospital, Linköping, Sweden

    O. I. Kolev MD PhD (Visiting Scientist), S. Pedersson MD PhD, G. Nilsson PhD & L. Tibbling MD PhD

Authors
  1. O. I. Kolev MD PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Pedersson MD PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Nilsson PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. Tibbling MD PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to O. I. Kolev MD PhD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kolev, O.I., Pedersson, S., Nilsson, G. et al. Cold caloric microcirculatory reflex disturbance in patients with Parkinson's disease. Clinical Autonomic Research 7, 81–83 (1997). https://doi.org/10.1007/BF02267751

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02267751

Keywords

Search

Navigation