Clinical Autonomic Research

, Volume 7, Issue 2, pp 77–80 | Cite as

Impairment of calcitonin gene-related peptide-induced potentiation of cholinergic sweat secretion in patients with multiple system atrophy

  • K. Kumazawa
  • G. Sobue
  • T. Mitsuma
  • J. Sugenoya
  • T. Ogawa
Research Paper


Loss of sweating is a characteristic feature of multiple system atrophy (MSA) with autonomic failure, and widespread anhidrosis may lead to hyperthermia and collapse in a hot environment. Calcitonin gene-related peptide (CGRP) is present in the periglandular nerves around sweat glands and is a strong stimulant of methacholine (MCH)-mediated cholinergic sweating. The present study evaluated CGRP-related regulation of cholinergic sweating in patients with MSA. CGRP-induced potentiation of MCH-mediated cholinergic sweating was significantly reduced in MSA patients as compared with normal age-matched controls. These results suggest that regulation of sweating is extensively affected in MSA as a consequence of peptidergic dysfunction.


multiple system atrophy sweat gland peptidergic regulation calcitonin gene-related peptide 


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Copyright information

© Rapid Science Publishers 1997

Authors and Affiliations

  • K. Kumazawa
    • 1
  • G. Sobue
    • 3
  • T. Mitsuma
    • 1
  • J. Sugenoya
    • 2
  • T. Ogawa
    • 2
  1. 1.Fourth Department of Internal MedicineAichi Medical UniversityAichiJapan
  2. 2.Department of PhysiologyAichi Medical UniversityAichiJapan
  3. 3.Department of NeurologyNagoya University, School of MedicineNagoyaJapan

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