Veterinary Science Communications

, Volume 1, Issue 1, pp 85–90 | Cite as

Histamine relaxes constricted trachea and bronchi of horse

  • N. Chand
  • P. Eyre


Horse trachea and bronchi contracted to slow-reacting substance of anaphylaxis, carbachol, 5-hydroxytryptamine, histamine, 2-methyl-histamine, bradykinin and prostaglandin F2α. Prostaglandins E1 and E2, isoprenaline and 4-methylhistamine caused relaxation of carbachol-contracted bronchi. Mepyramine (H1-blocker) specifically inhibited histamine bronchoconstriction. In the presence of mepyramine, histamine caused relaxation of carbachol-contracted bronchi. Metiamide (H2-blocker) inhibited histamine bronchorelaxation but not relaxation of the trachea. This suggests (1) the presence of both H1- and H2-receptors mediating bronchoconstriction and relaxation respectively (2) the existence of an “atypical” histamine receptor in the trachea. The study suggests that in equine respiratory hypersensitivity under therapy with classical (H1) antihistaminics, further release of histamine may exert a beneficial broncholytic effect on airways contracted by other chemical mediators of immediate-type inflammation.


Public Health Histamine Prostaglandin Veterinary Medicine Bradykinin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Elsevier Scientific Publishing Company 1977

Authors and Affiliations

  • N. Chand
    • 1
  • P. Eyre
    • 1
  1. 1.Pharmacology Laboratory, Ontario Veterinary CollegeUniversity of GuelphGuelphCanada

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