Human Genetics

, Volume 97, Issue 2, pp 163–170 | Cite as

A common region of loss of heterozygosity in Wilms' tumor and embryonal rhabdomyosarcoma distal to the D11S988 locus on chromosome 11p15.5

  • Corinne Besnard-Guérin
  • Irene Newsham
  • Robert Winqvist
  • Webster K. Cavenee
Original Investigation

Abstract

The development of Wilms' tumor has been associated with two genetic loci on chromosome 11: WTI in 11p13 and WT2 in 11p15.5. Here, we have used loss of heterozygosity (LOH) in Wilms' tumors to narrow the WT2 locus distal to the D11S988 locus. A similar region was apparent for the clinically associated tumor, embryonal rhabdomyosarcoma. We have also demonstrated that a constitutional chromosome translocation breakpoint associated with Beckwith-Wiedemann syndrome and an acquired somatic chromosome translocation breakpoint in a rhabdoid tumor each occur in the same chromosomal interval as the smallest region of LOH in Wilms' tumors and embryonal rhabdomyosarcoma. Finally, we report the first Wilms' tumor without a cytogenetic deletion that shows targeted LOH for 11p15 and 11p13 while maintaining germline status for 11p14.

Keywords

Metabolic Disease Small Region Chromosome 11p15 Genetic Locus Rhabdomyosarcoma 

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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Corinne Besnard-Guérin
    • 1
  • Irene Newsham
    • 1
    • 2
  • Robert Winqvist
    • 3
  • Webster K. Cavenee
    • 1
    • 2
    • 3
  1. 1.Ludwig Institute for Cancer ResearchUniversity of California San-Diego, School of MedicineLa JollaUSA
  2. 2.Department of MedicineUniversity of California San-Diego, School of MedicineLa JollaUSA
  3. 3.Center for Molecular GeneticsUniversity of California San-Diego, School of MedicineLa JollaUSA

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