Inflammation Research

, Volume 45, Issue 3, pp 150–154 | Cite as

Effects of metamizol on nociceptive responses to stimulation of the ureter and on ureter motility in anaesthetised rats

  • J. M. A. Laird
  • F. Cervero
Original Research Papers


In this study, we have examined the effects of metamizol (dipyrone), a non-opioid analgesic which is effective in relieving renal colic pain, on nociceptive responses evoked by stimulation of the ureter, on pyeloureteral motility and on intraureter pressure after ureter obstruction in anaesthetised rats. Metamizol (5–50 mg/kg i.v.) dose-dependently inhibited reflex pressor responses evoked by distensions of the ureter to pressures of 30, 55 and 75 mmHg for 30 s (ID50=8±1 mg/kg). Metamizol also dose-dependently reduced intraureter pressure during total ureter occlusion (25 mg/kg produced a reduction of 25% in 10 min). However, metamizol at doses up to 50 mg/kg had no effect on pyleoureteric motility (contraction amplitude, rate or intraureter pressure) under normal pressure conditions. We conclude that metamizol has a direct antinociceptive action on pain of ureteric origin, and spasmolytic effects after ureter obstruction (but not under normal conditions) which may also contribute to pain relief.

Key words

Analgesia Pain Renal colic Dipyrone Cyclooxygenase 


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Copyright information

© Birkhäuser Verlag 1996

Authors and Affiliations

  • J. M. A. Laird
    • 1
  • F. Cervero
    • 1
  1. 1.Department of Physiology and Pharmacology, Faculty of MedicineUniversity of Alcalá de HenaresMadridSpain

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