Skip to main content
Log in

Substrate inhibition of HGPRT: Protein structural and kinetic studies of a human variant

  • Work In Progress
  • Published:
Journal of Inherited Metabolic Disease

Abstract

Kinetic and electrophoretic properties of a new mutant form of hypoxanthine-guanine phosphoribosyltransferase are described.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Arnold, W. J. and Kelley, W. N. Human hypoxanthine-guanine phosphoribosyltransferase. Purification and subunit structure.J. Biol. Chem. 246 (1971) 7398–7404

    Google Scholar 

  • Cassidy, M., Gregory, M. C. and Harley, E. H. Primary overproduction of urate caused by a partial deficiency of hypoxanthine-guanine phosphoribosyltransferase.S. Afr. Med. J. 57 (1980) 948–950

    Google Scholar 

  • Giacomello, A. and Salerno, C. A continuous spectrophotometric assay for hypoxanthine-guanine phosphoribosyltransferase.Anal. Biochem. 79 (1977) 263–267

    Google Scholar 

  • Shnier, M. H., Sims, F. and Zail, S. The Lesch-Nyhan syndrome. First case description in a South African family.S. Afr. Med. J. 46 (1972) 947–949

    Google Scholar 

  • Wilkinson, G. N. Statistical estimations in enzyme kinetics.Biochem. J. 80 (1961) 324–332

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Steyn, L.M., Harley, E.H. Substrate inhibition of HGPRT: Protein structural and kinetic studies of a human variant. J Inherit Metab Dis 4, 115–116 (1981). https://doi.org/10.1007/BF02263617

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02263617

Keywords

Navigation