Abstract
Recent work leading to the production of resealed erythrocytes with enhancedin vivo survival is reviewed. The term ‘carrier erythrocytes’ is proposed for these cells and possible therapeutic uses are discussed.
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Hubbard, A. R., Sprandel, E. and Chalmers, R. A. Organic acid transport in resealed haemoglobin-containing human erythrocyte ‘ghosts’.Biochem J. 190 (1980a) 653–658
Hubbard, A. R., Sprandel, U. and Chalmers, R. A. Dependance of mouse erythrocyte ‘ghosts’ survivalin vivo on cellular ATP concentrations.Biochem. Soc. Trans. 8 (1980b) 578
Ihler, G. M., Glew, R. H. and Schnure, F. W. Enzyme loading of erythrocytes.Proc. Natl. Acad. Sci. USA 70 (1973) 2663–2666
Sprandel, U., Clark, J. B., Hubbard, A. R. and Chalmers, R. A. Morphology of haemoglobin-containing human erythrocyte ‘ghosts’,Micron 12 (1981) 29–36
Sprandel, U., Hubbard, A. R. and Chalmers, R. A.In vitro studies on resealed erythrocyte ‘ghosts’ as protein carriers.Res. Exp. Med. (Berl.). 175 (1979a) 239–245
Sprandel, U., Hubbard, A. R. and Chalmers, R. A. Membrane transport in resealed haemoglobin-containing human erythrocyte ‘ghosts’ prepared by a dialysis procedure.Biochem. Biophys. Res. Commun. 91 (1979b) 79–85 [93, 341–342]
Thorpe, S. R., Fiddler, M. B. and Desnick, R. J. Enzyme therapy. V.In vivo fate of erythrocyte-entrapped β-glucuronidase in β-glucuronidase-deficient mice.Pediatr. Res. 9 (1975) 918–923
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On leave from Medizinische Poliklinik der Universität München, Pettenkoferstr. 8a, D-8000 München 2, Federal Republic of Germany
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Sprandel, U., Hubbard, A.R. & Chalmers, R.A. Towards enzyme therapy using carrier erythrocytes. J Inherit Metab Dis 4, 99–100 (1981). https://doi.org/10.1007/BF02263610
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DOI: https://doi.org/10.1007/BF02263610